Clone:
DTA-1
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
rat IgG2bκ
Applications:
FA, FC, MICS, IF, IHC
Alternative names:
TNFRSF18, AITR

Specifications for CD357 (GITR) Antibody, anti-mouse

Overview

Clone DTA-1 specifically recognizes mouse CD357, also known as glucocorticoid-induced TNF-receptor (GITR) or TNFRSF18, a member of the TNF receptor superfamily. It is expressed at low levels on resting T lymphocytes and at high levels on CD4
+
CD25
+
regulatory T cells (Tregs). Activation of T cells upregulates GITR expression. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation. GITR plays an important role in the function of CD4
+
CD25
+
Tregs.

Alternative names

TNFRSF18, AITR

Detailed product information

Technical specifications

CloneDTA-1
Clonalitymonoclonal
Isotyperat IgG2bκ
Isotype controlIsotype Control Antibody, rat IgG2b
Hostrat
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesmouse
AntigenCD357 (GITR)
Alternative names of antigenTNFRSF18, AITR
Molecular mass of antigen [kDa]23
Entrez Gene ID21936
RRIDAB_871551, AB_2659972, AB_2659973, AB_871550, AB_871552

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