Clone:
REA1163
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MC
Alternative names:
NCR2, LY95, NKp44

Specifications for CD336 (NKp44) Antibody, anti-human, REAfinity™

Overview

Clone REA1163 recognizes the human CD336 antigen, also known as NKp44. CD336 is a member of the natural cytotoxicity receptor (NCR) family which trigger cytotoxicity in natural killer (NK) cells. CD336 is directly involved in target cell recognition and lysis and is only expressed by activated NK cells, e.g., NK cells cultured in the presence of interleukin 2 (IL-2). Freshly isolated, resting NK cells do not express CD336.
Additional information: Clone REA1163 displays negligible binding to Fc receptors.

Alternative names

NCR2, LY95, NKp44

Detailed product information

Technical specifications

CloneREA1163
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD336 (NKp44)
Alternative names of antigenNCR2, LY95, NKp44
Molecular mass of antigen [kDa]28
Distribution of antigenNK cells, T cells
Entrez Gene ID9436
RRIDAB_2784142, AB_2784139, AB_2784138, AB_2784145, AB_2784144, AB_2784147, AB_2784146, AB_2784141, AB_2784140, AB_2784143

References for CD336 (NKp44) Antibody, anti-human, REAfinity™

Publications

  1. Vitale, M. et al. (1998) NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis. J. Exp. Med. 187: 2065-2072
  2. Sivori, S. et al. (2000) 2B4 functions as a co-receptor in human NK cell activation. Eur. J. Immunol. 30: 787-793
  3. Moretta, A. et al. (2001) Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19: 197-223
  4. Chaput, N. et al. (2013)
    Phase I clinical trial combining imatinib mesylate and IL-2: HLA-DR
    +
    NK cell levels correlate with disease outcome.
    Oncoimmunology 2(2): e23080

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