Clone:
REA391
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
FCRL5, BXMAS1, CD307, FCRH5, IRTA2, PRO820

Specifications for CD307e (FcRL5) Antibody, anti-human, REAfinity™

Overview

Clone REA391 recognizes the human CD307e antigen, a 106 kDa single-pass type I membrane protein also known as Fc receptor-like protein 5 (FcRL5) or immune receptor translocation-associated protein 2 (IRTA2). CD307e possesses a cytoplasmic tail with inhibitory ITIM phosphorylation signaling motifs and was found to inhibit B cell antigen receptor signaling by recruiting SHP1 to two ITIM motifs upon B cell antigen receptor co-stimulation, resulting in diminished calcium influx and protein tyrosine phosphorylation. Co-stimulation of CD307e and the B cell antigen receptor promotes proliferation and differentiation of naive B cells. CD307e is expressed on both mature B cells and plasma cells, and is induced by EBV proteins. It is overexpressed on malignant B cells of hairy cell leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, and multiple myeloma patients. In addition, serum levels of soluble CD307e are elevated in patients with several types of B cell tumors.
Additional information: Clone REA391 displays negligible binding to Fc receptors.

Alternative names

FCRL5, BXMAS1, CD307, FCRH5, IRTA2, PRO820

Detailed product information

Technical specifications

CloneREA391
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD307e (FcRL5)
Alternative names of antigenFCRL5, BXMAS1, CD307, FCRH5, IRTA2, PRO820
Molecular mass of antigen [kDa]105
Distribution of antigenB cells, plasma cells
Entrez Gene ID83416
RRIDAB_2657257, AB_2657258, AB_2657259, AB_2657260

References for CD307e (FcRL5) Antibody, anti-human, REAfinity™

Publications

  1. Miller, I. et al. (2002) IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells. Blood 99(8): 2662-2669
  2. Zhu, Z. et al. (2013) FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling. Proc. Natl. Acad. Sci. U.S.A. 110(14): E1282-E1290
  3. Nakayama, Y. et al. (2001) BXMAS1 identifies a cluster of homologous genes differentially expressed in B cells. Biochem. Biophys. Res. Commun. 285(3): 830-837

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