Clone:
UP-H2
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
CD300LE, CLM-2, CMRF35-A5, IREM-2, PIgR-2, LMIR6

Specifications for CD300e (IREM-2) Antibody, anti-human

Overview

The monoclonal antibody UP-H2 reacts with human CD300e, also known as IREM-2, LMIR6, or CMRF35-A5. This 34 kDa activating receptor of the immunglobulin superfamily is expressed on mature myeloid dendritic cells and monocytes and is down-regulated on immature dendritic cells. CD300e interacts with DAP-12, which mediates acivating signals. It is reported that the alloreactive response of naive T cells is enhanced by IREM-2 activation of mDCs.

Alternative names

CD300LE, CLM-2, CMRF35-A5, IREM-2, PIgR-2, LMIR6

Detailed product information

Technical specifications

CloneUP-H2
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD300e (IREM-2)
Alternative names of antigenCD300LE, CLM-2, CMRF35-A5, IREM-2, PIgR-2, LMIR6
Distribution of antigendendritic cells, monocytes
RRIDAB_2801843, AB_2657138, AB_2657139, AB_2657140, AB_2657141, AB_2657144, AB_2657145, AB_2657146, AB_2657147, AB_2657148, AB_2657149, AB_2657150, AB_2657151, AB_2657152, AB_2657153, AB_2801847

References for CD300e (IREM-2) Antibody, anti-human

Publications

  1. Aguilar, H. et al. (2004) Molecular characterization of a novel immune receptor restricted to the monocytic lineage. J. Immunol. 173: 6703-6711
  2. Brckalo, T. et al. (2010) Functional analysis of the CD300e receptor in human monocytes and myeloid dendritic cells. Eur. J. Immunol. 40(3): 722-732

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