Clone:
REA1085
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TNFRSF8, Ki-1, Ber-H2

Specifications for CD30 Antibody, anti-human, REAfinity™

Overview

Clone REA1085 recognizes the human CD30 antigen, a cell membrane protein, which is a member of the tumor necrosis factor receptor (TNFR) superfamily, and also known as Ki-1. CD30 is used as a tumor marker and is found on Hodgkin/Reed-Sternberg (H/RS) cells, embryonal carcinoma cells, and on activated T and B lymphocytes. It functions as a receptor for TNFSF8/CD30L and is involved in the regulation of cellular growth and transformation of activated lymphoblasts and regulates signal transduction by activation of NF-κB.
Additional information: Clone REA1085 displays negligible binding to Fc receptors.

Alternative names

TNFRSF8, Ki-1, Ber-H2

Detailed product information

Technical specifications

CloneREA1085
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD30
Alternative names of antigenTNFRSF8, Ki-1, Ber-H2
Molecular mass of antigen [kDa]62
Distribution of antigenB cells, T cells, other
Entrez Gene ID943
RRIDAB_2733635, AB_2733804, AB_2733805, AB_2733370, AB_2733371, AB_2733938, AB_2733939, AB_2732974, AB_2732975, AB_2733223, AB_2733224, AB_2733116, AB_2733117, AB_2733029, AB_2733030, AB_2734015, AB_2734016, AB_2733518, AB_2733519, AB_2733634

References for CD30 Antibody, anti-human, REAfinity™

Publications

  1. Lee, S. Y. et al. (1996) T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors. J. Exp. Med. 183(2): 669-674
  2. Aizawa, S. et al. (1997) Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. J. Biol. Chem. 272(4): 2042-2045
  3. Kimmig, S. et al. (2002) Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J. Exp. Med. 195: 789-794

Related products for
CD30 Antibody, anti-human, REAfinity™

3 products available