Clone:
HK5.3
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
rat IgG2aκ
Applications:
FA, FC
Alternative names:
ICOSL, B7-H2, B7RP-1, B7h, ICOSLG, LICOS, Ly115l, GL50, GL50-B

Specifications for CD275 (B7-H2) Antibody, anti-mouse

Overview

Clone HK5.3 recognises murine CD275, which is also known as B7-H2 and ICOSL. CD275 is a type I membrane protein and belongs to the Ig superfamily, B7 family of costimulatory molecules. Expression of CD275 is found on antigen presenting cells such as B cells, dendritic cells, and monocytes. CD275 costimulates T cells upon binding to ICOS, which is expressed on activated T cells. In mouse, CD275 binds only ICOS, whereas in humans it can interact with other T cell costimulatory molecules, CD28 and CTLA-4. To appropriately regulate the activation of immune response, the ICOS-CD275 interaction can also lead to downregulation of CD275 expression which allows prevention of hyperreaction of T cells.

Alternative names

ICOSL, B7-H2, B7RP-1, B7h, ICOSLG, LICOS, Ly115l, GL50, GL50-B

Detailed product information

Technical specifications

CloneHK5.3
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesmouse
AntigenCD275 (B7-H2)
Alternative names of antigenICOSL, B7-H2, B7RP-1, B7h, ICOSLG, LICOS, Ly115l, GL50, GL50-B
Molecular mass of antigen [kDa]31
Distribution of antigendendritic cells, macrophages, monocytes
Entrez Gene ID50723
RRIDAB_2656897, AB_2656898, AB_2656899, AB_2656900, AB_2656901, AB_2656902, AB_2656903, AB_2656904, AB_2656886

References for CD275 (B7-H2) Antibody, anti-mouse

Publications

  1. Watanabe, M. et al. (2008) Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses. J. Immunol. 180: 5222-5234
  2. Yao, S. et al. (2011) B7-H2 is a costimulatory ligand for CD28 in human. Immunity 34(5): 729-740

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