Clone:
REA550
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TNFRSF17, Bcm, BCMA, Tnfrsf13, Tnfrsf13a

Specifications for CD269 (BCMA) Antibody, anti-mouse, REAfinity™

Overview

Clone REA550 recognizes the mouse CD269 antigen, which is also known as B cell maturation protein BCMA. CD269 is a member of the TNF receptor superfamily. Its binding to BLyS and APRIL activates transcription factor NF-κB and stimulates IgM production by peripheral blood B cells. A soluble form of BCMA, which inhibits the proliferative activity of APRIL
in vitro
, decreases tumor cell proliferation in nude mice. CD269 has been detected in immune organs such as spleen, thymus, bone marrow, and heart, as well as at lower levels in kidney and lung and is preferentially expressed in mature B lymphocytes.
Additional information: Clone REA550 displays negligible binding to Fc receptors.

Alternative names

TNFRSF17, Bcm, BCMA, Tnfrsf13, Tnfrsf13a

Detailed product information

Technical specifications

CloneREA550
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD269 (BCMA)
Alternative names of antigenTNFRSF17, Bcm, BCMA, Tnfrsf13, Tnfrsf13a
Molecular mass of antigen [kDa]20
Distribution of antigenB cells
Entrez Gene ID21935
RRIDAB_2801983, AB_2656794, AB_2656795, AB_2656800, AB_2656801, AB_2656802, AB_2656803, AB_2656804, AB_2656805, AB_2784095

References for CD269 (BCMA) Antibody, anti-mouse, REAfinity™

Publications

  1. Rennert, P. et al. (2000) A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member april, inhibits tumor cell growth. J. Exp. Med. 192: 1677-1684
  2. Madry, C. et al. (1998) The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily. Int. Immunol. 10(11): 1693-1702
  3. Marsters, S. A. et al. (2000) Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr. Biol. 10(13): 785-788

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