Clone:
MD5-1-3C2
Type of antibody:
Primary antibodies
Isotype:
hamster IgG
Applications:
FC
Alternative names:
TNFRSF10B, DR5, KILLER, Ly98, MK, TRAIL-R2, TRICK2A, TRICK2B, TRICKB

Specifications for CD262 Antibody, anti-mouse

Overview

CD262 is a 55 kDa protein expressed on leukocytes, placenta cells, liver cells and some tumor cells and tumor cell lines (such as NIH-3T3). CD262 is also known as DR5, TRAIL-R2, and TNFRSF10B. CD262 is a receptor for TRAIL, its binding induces apoptosis by activating the NF-κB pathway.

Alternative names

TNFRSF10B, DR5, KILLER, Ly98, MK, TRAIL-R2, TRICK2A, TRICK2B, TRICKB

Detailed product information

Technical specifications

CloneMD5-1-3C2
Clonalitymonoclonal
Isotypehamster IgG
Hosthamster
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD262
Alternative names of antigenTNFRSF10B, DR5, KILLER, Ly98, MK, TRAIL-R2, TRICK2A, TRICK2B, TRICKB
Molecular mass of antigen [kDa]37
Distribution of antigenleukocytes, thymocytes, heart, liver, lung, ovary, pancreas, placenta, spleen
Entrez Gene ID21933
RRIDAB_2656747, AB_2656748, AB_2656749, AB_2656750, AB_2656751, AB_2656752, AB_2656753, AB_2656754, AB_2656755, AB_2656746

References for CD262 Antibody, anti-mouse

Publications

  1. Hayakawa, Y. et al. (2004)
    NK cell TRAIL eliminates immature dendritic cells
    in vivo
    and limits dendritic cell vaccination efficacy.
    J. Immunol. 172(1): 123-129
  2. Sato, K. et al. (2005) TRAIL-transduced dendritic cells protect mice from acute graft-versus-host disease and leukemia relapse. J. Immunol. 174(7): 4025-4033
  3. Takeda, K. et al. (2004) Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy. J. Exp. Med. 4(199): 437-448
  4. Grisendi, G. et al. (2010) Adipose-derived mesenchymal stem cells as stable source of tumor necrosis factor-related apoptosis-inducing ligand delivery for cancer therapy. Cancer Res. 70(9): 3718-3729
  5. Shanker, A. et al. (2008) Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody. J. Natl. Cancer Inst. 100(9): 649-662
  6. Iannello, A. et al. (2009) Potential role of interleukin-18 in the immunopathogenesis of AIDS: involvement in fratricidal killing of NK cells. J. Virol. 83(12): 5999-6010

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CD262 Antibody, anti-mouse

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