Clone:
REA347
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
TNFSF13, A proliferation-inducing ligand (APRIL), TALL-2, TALL2, TRDL-1, UNQ383/PRO715, ZTNF2, April

Specifications for CD256 (APRIL) Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA347 recognizes the human and mouse CD256 antigen, a protein which is a member of the TNF ligand superfamily and also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13) or a proliferation-inducing ligand (APRIL). CD256 is expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues, and specifically expressed in monocytes and macrophages. Secreted CD256 consists almost entirely of a single TNF homology domain. Little or no transmembrane CD256 is expressed on the cell surface. CD256 binds with high affinity the TNFR family members B cell maturation antigen (BCMA) and transmembrane activator and CAML-interactor (TACI). It stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-κB, and induces cell death. CD256 and its receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.
Additional information: Clone REA347 displays negligible binding to Fc receptors.

Alternative names

TNFSF13, A proliferation-inducing ligand (APRIL), TALL-2, TALL2, TRDL-1, UNQ383/PRO715, ZTNF2, April

Detailed product information

Technical specifications

CloneREA347
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenCD256 (APRIL)
Alternative names of antigenTNFSF13, A proliferation-inducing ligand (APRIL), TALL-2, TALL2, TRDL-1, UNQ383/PRO715, ZTNF2, April
Molecular mass of antigen [kDa]16
Distribution of antigenmonocytes, macrophages
Entrez Gene ID8741
RRIDAB_2733361, AB_2752193, AB_2752174, AB_2656703, AB_2656704, AB_2656705, AB_2656706, AB_2733360

References for CD256 (APRIL) Antibody, anti-human/mouse, REAfinity™

Publications

  1. Yu, G. et al. (2000) APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat. Immunol. 1(3): 252-256
  2. Hahne, M. et al. (1998) APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J. Exp. Med. 188(6): 1185-1190
  3. Vincent, F. B. et al. (2013) The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity. Cytokine Growth Factor Rev. 24(3): 203-215

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