Clone:
RM134L
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
rat IgG2bκ
Applications:
FA, FC, MICS, IF, IHC
Alternative names:
TNFSF4, Ath-1, Ath1, CD134L, OX40L, Txgp1, Txgp1l, gp34

Specifications for CD252 (OX40L) Antibody, anti-mouse

Overview

Clone RM134L recognizes CD252 (OX40L), a ligand of OX40 receptor, belonging to the TNF superfamily. Expression of CD252 can be induced on B cells, dendritic cells, macrophages, mast cells, natural killer (NK) cells, endothelial cells, and smooth muscle cells. Expression of the cognate receptor OX40 is found on activated CD4 cells, CD8 cells, regulatory T cells, NKT cells, NK cells, and neutrophils, but the function of OX40 signaling is extensively studied only in T cells. CD252 (OX40L)-OX40 interaction promotes the proliferation and surival of effector T cells, modulates cytokine production, suppresses the activity of natural regulatory T cells (nTreg), and inhibits the generation of inducible Treg cells.

Alternative names

TNFSF4, Ath-1, Ath1, CD134L, OX40L, Txgp1, Txgp1l, gp34

Detailed product information

Technical specifications

CloneRM134L
Clonalitymonoclonal
Isotyperat IgG2bκ
Isotype controlIsotype Control Antibody, rat IgG2b
Hostrat
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesmouse
AntigenCD252 (OX40L)
Alternative names of antigenTNFSF4, Ath-1, Ath1, CD134L, OX40L, Txgp1, Txgp1l, gp34
Molecular mass of antigen [kDa]22
Distribution of antigenB cells, dendritic cells, endothelial cells, mast cells, monocytes, T cells, leukemia cells, thymocytes, heart, spleen
Entrez Gene ID22164
RRIDAB_2656670, AB_2656671, AB_2656672, AB_2656673, AB_2656674, AB_2656675, AB_2656668

References for CD252 (OX40L) Antibody, anti-mouse

Publications

  1. Akiba, H. et al. (1999) CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J. Immunol. 162(12): 7058-7066
  2. Croft, M. et al. (2009) The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol. Rev. 229(1): 173-191
  3. Ishii, N. et al. (2010) OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology. Adv. Immunol. 105: 63-98

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CD252 (OX40L) Antibody, anti-mouse

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