Clone:
REA960
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
OX40L, TNFSF4, Ath-1, Ath1, CD134L, Txgp1, Txgp1l, gp34

Specifications for CD252 (OX40L) Antibody, anti-mouse, REAfinity™

Overview

Clone REA960 recognizes the mouse CD252 antigen, also known as OX40L, a ligand of the OX40 receptor belonging to the TNF superfamily. Expression of CD252 can be induced on B cells, dendritic cells, macrophages, mast cells, NK cells, endothelial cells, and smooth muscle cells. Expression of the cognate receptor OX40, is found on activated CD4 cells, CD8 cells, regulatory T cells, NKT cells, NK cells, and neutrophils, but the function of OX40 signaling is extensively studied only in T cells. CD252–OX40 interaction promotes the proliferation and surival of effector T cells, modulates cytokine production, suppresses the activity of natural regulatory T cells (nTreg) and inhibits the generation of inducible Treg cells.
Additional information: Clone REA960 displays negligible binding to Fc receptors.

Alternative names

OX40L, TNFSF4, Ath-1, Ath1, CD134L, Txgp1, Txgp1l, gp34

Detailed product information

Technical specifications

CloneREA960
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD252 (OX40L)
Alternative names of antigenOX40L, TNFSF4, Ath-1, Ath1, CD134L, Txgp1, Txgp1l, gp34
Molecular mass of antigen [kDa]22
Distribution of antigenB cells, dendritic cells, endothelial cells, mast cells, monocytes, T cells, leukemia cells, thymocytes, heart, spleen
Entrez Gene ID22164
RRIDAB_2727327, AB_2727294, AB_2727328, AB_2727295, AB_2727329, AB_2727296, AB_2727325, AB_2727326

References for CD252 (OX40L) Antibody, anti-mouse, REAfinity™

Publications

  1. Akiba, H. et al. (1999) CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J. Immunol. 162(12): 7058-7066
  2. Croft, M. et al. (2009) The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol. Rev. 229(1): 173-191
  3. Ishii, N. et al. (2010) OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology. Adv. Immunol. 105: 63-98

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