Clone:
REA260
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
INSR, HHF5

Specifications for CD220 Antibody, anti-human, REAfinity™

Overview

Clone REA260 recognizes the CD220 antigen, a type I transmembrane receptor tyrosine kinase, which is also known as insulin receptor (IR). CD220 is predominantly expressed in major target tissues of insulin metabolic effects like liver, adipose tissue, and skeletal muscle, but is also expressed in the peripheral nerve, kidney, fibroblasts, monocytes, granulocytes, erythrocytes, and skin. It is composed of two extracellular α-subunits and two transmembrane β-subunits. Upon binding of insulin, CD220 forms a heterotetramer of two units to induce autophosphorylation and activation of the tyrosine kinase activity of the receptor. CD220 plays a key role in the regulation of glucose homeostasis, cell growth, differentiation, and apoptosis- functional processes that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer.
Additional information: Clone REA260 displays negligible binding to Fc receptors.

Alternative names

INSR, HHF5

Detailed product information

Technical specifications

CloneREA260
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD220
Alternative names of antigenINSR, HHF5
Molecular mass of antigen [kDa]307(sum of molecular weights of subunits)
Distribution of antigenmonocytes, fibroblasts, red blood cells, granulocytes, liver
Entrez Gene ID3643
RRIDAB_2656379, AB_2656380, AB_2656381, AB_2656382, AB_2656383, AB_2656384

References for CD220 Antibody, anti-human, REAfinity™

Publications

  1. Youngren, J. F. et al. (2007) Regulation of insulin receptor function. Cell. Mol. Life Sci. 64(7-8): 873-891
  2. Czech, M. P. et al. (1985) The nature and regulation of the insulin receptor: structure and function. Annu. Rev. Physiol. 47: 357-381
  3. Chiu, S. L. et al. (2010) Insulin receptor signaling in the development of neuronal structure and function. Neural Dev. 5: 7

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