Clone:
REA128
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
OX-2 receptor 3

Specifications for CD200R3 Antibody, anti-mouse, REAfinity™

Overview

Clone REA128 recognizes the human CD200R3 antigen. CD200R is an approximately 33 kDa single-pass type I membrane-protein which is a disulfide-linked dimer on the cell surface. It is reported, that the four different isoforms of CD200R (CD200R1, CD200R2, CD200R3, CD200R4) bind to CD200 (OX-2) as ligand. CD200 is primarily expressed on myeloid cells but also expressed on T and B lymphocytes. The combination of CD200R and CD200 inhibits mast cell degranulation, promotes macrophage activation, and decreases the activation of lymphocytes.
Additional information: Clone REA128 displays negligible binding to Fc receptors.

Alternative names

OX-2 receptor 3

Detailed product information

Technical specifications

CloneREA128
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD200R3
Alternative names of antigenOX-2 receptor 3
Molecular mass of antigen [kDa]31
Distribution of antigenT cells, B cells
Entrez Gene ID74603
RRIDAB_2656119, AB_2656120, AB_2656121, AB_2656122, AB_2656123, AB_2656124, AB_2656125, AB_2656126, AB_2656127, AB_2656118

References for CD200R3 Antibody, anti-mouse, REAfinity™

Publications

  1. Gorczynski, R. et al. (2004) CD200 is a ligand for all members of the CD200R family of immunoregulatory molecules. J. Immunol. 172: 7744-7749
  2. Wright, G. J. et al. (2003) Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. J. Immunol. 171: 3034-3046
  3. Rijkers, E. S. et al. (2008) The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes. Mol. Immunol. 45(4): 1126-1135

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CD200R3 Antibody, anti-mouse, REAfinity™

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