Clone:
REA1193
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CXC-R6, CXCR-6, CXCR6, BONZO, STRL33

Specifications for CD186 (CXCR6) Antibody, anti-mouse, REAfinity™

Overview

Clone REA1193 recognizes the mouse CD186 chemokine receptor, which is also known as Cxcr6 (receptor for the C-X-C chemokine CXCL16). CD186 is expressed by naive CD8 T cells, natural killer T cells, and a subset of memory CD4 T cells.
The chemokine CXCL16 is produced by dendritic cells (DCs) in lymphoid organ T cell zones and by cells in the splenic red pulp. It is reported, that CXCL16 plays a role in promoting interactions between DCs and CD8 T cells and in guiding T cell movements in the splenic red pulp.Furthermore, CXCL16 and CXCR6 play an essential role in the maintenance of cardiac allograft tolerance mediated by NKT cells.
Additional information: Clone REA1193 displays negligible binding to Fc receptors.

Alternative names

CXC-R6, CXCR-6, CXCR6, BONZO, STRL33

Detailed product information

Technical specifications

CloneREA1193
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD186 (CXCR6)
Alternative names of antigenCXC-R6, CXCR-6, CXCR6, BONZO, STRL33
Molecular mass of antigen [kDa]41
Distribution of antigenT cells, NKT cells, CD4+ T cells, CD8+ T cells, naive T cells, memory T cells
Entrez Gene ID80901
RRIDAB_2819421, AB_2819422, AB_2819423, AB_2819420

References for CD186 (CXCR6) Antibody, anti-mouse, REAfinity™

Publications

  1. Matloubian, M. et al. (2000) A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat. Immunol. 1(4): 298-304
  2. Jiang, X. et al. (2005) Cutting edge: critical role of CXCL16/CXCR6 in NKT cell trafficking in allograft tolerance. J. Immunol. 175(4): 2051-2055