Clone:
REA1077
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC, MC
Alternative names:
CD33L2, OB-BP2, OBBP2, Siglec-5

Specifications for CD170 (Siglec-5) Antibody, anti-human, REAfinity™

Overview

Clone REA1077 recognizes the CD170 antigen, a single-pass transmembrane protein member of the immunoglobulin superfamily, also known as sialic acid-binding Ig-like lectin 5 (Siglec-5). CD170 is expressed on neutrophils, monocytes, dendritic cells, and subsets of tissue macrophages. It contains two tyrosine-based motifs in its cytoplasmic tail implicating signaling functions and forms a 140 kDa dimer on the cell surface. Tyrosine phosphorylation of CD170 leads to recruitment of the tyrosine phosphatases SHP-1 and SHP-2, which in turn efficiently inhibits FcεRI-mediated calcium fluxing and serotonin release. CD170 binds α 2-3- and α 2-6-linked sialic acid as well as glycophorin A, and is involved in cell adhesion.
Additional information: Clone REA1077 displays negligible binding to Fc receptors.

Alternative names

CD33L2, OB-BP2, OBBP2, Siglec-5

Detailed product information

Technical specifications

CloneREA1077
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivity
chimpanzee (
Pan troglodytes
)
,
bonobo (
Pan paniscus
)
AntigenCD170 (Siglec-5)
Alternative names of antigenCD33L2, OB-BP2, OBBP2, Siglec-5
Molecular mass of antigen [kDa]59
Distribution of antigendendritic cells, macrophages, monocytes, neutrophils
Entrez Gene ID8778
RRIDAB_2751604, AB_2751653, AB_2751605, AB_2751654, AB_2751606, AB_2751655, AB_2751607, AB_2751656, AB_2751608, AB_2751657, AB_2751609, AB_2751658, AB_2751610, AB_2751652

References for CD170 (Siglec-5) Antibody, anti-human, REAfinity™

Publications

  1. Cornish, A. L. et al. (1998) Characterization of Siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. Blood 92(6): 2123-2132
  2. Erickson-Miller, C. L. et al. (2003) Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes. Exp. Hematol. 31(5): 382-388
  3. Avril, T. et al. (2005) Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. J. Biol. Chem. 280: 19843-19851

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