Clone:
7-239
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
MC, FC, MICS, IF, IHC
Alternative names:
Siglec-1, SN

Specifications for CD169 (Siglec-1) Antibody, anti-human

Overview

The monoclonal antibody 7-239 reacts with CD169, also known as siglec-1 or sialoadhesin, which is a type I transmembrane glycoprotein. It is the largest member of the siglec family, which are cell surface lectins that are able to bind to sialic acids and mediate interactions between proteins and carbohydrates. Siglec-1 is mainly expressed on tissue macrophages and dendritic cells and interacts with its counterreceptor on T cells, which has been identified as CD43.

Alternative names

Siglec-1, SN

Detailed product information

Technical specifications

Clone7-239
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD169 (Siglec-1)
Alternative names of antigenSiglec-1, SN
Molecular mass of antigen [kDa]181
Distribution of antigenmacrophages, bone marrow, spleen
Entrez Gene ID6614
RRIDAB_2655544, AB_2655545, AB_2655546, AB_2655547, AB_2655548, AB_2655549, AB_2655550, AB_2655551, AB_2655552, AB_2655553, AB_2655554, AB_2655555, AB_2655556

References for CD169 (Siglec-1) Antibody, anti-human

Publications

  1. van den Berg, T. K. et al. (2001) Cutting Edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor Sialoadhesin (Siglec-1). J. Immunol. 166: 3637- 3640
  2. Hartnell, A. et al. (2001) Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. Blood 97: 288-296
  3. Crocker, P.R. et al. (2001) Siglecs, sialic acids and innate immunity. Trends Immunol. 22(6): 337-342

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