Clone:
67D2
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
MGC-24, MUC-24, Endolyn

Specifications for CD164 Antibody, anti-human

Overview

Clone 67D2 recognizes the human CD164 antigen, a single-pass type I membrane protein, which is also known as sialomucin core protein 24, multi-glycosylated core protein 24 (MUC-24), or endolyn. CD164 is expressed by subpopulations of CD34
+
cells. These include the majority of clonogenic myeloid and erythroid progenitors and the hierarchically more primitive precursors. Biochemical and functional characterization of CD164 indicate that this protein exists as a homodimeric molecule of approximately 160 kDa that participates in the adhesion of CD34
+
cells to bone marrow stroma and functions as a signaling molecule, inhibiting the recruitment of primitive hematopoietic cells into cell cycle. CD164 may also play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells.

Alternative names

MGC-24, MUC-24, Endolyn

Detailed product information

Technical specifications

Clone67D2
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD164
Alternative names of antigenMGC-24, MUC-24, Endolyn
Molecular mass of antigen [kDa]19
Distribution of antigenother, liver
Entrez Gene ID8763
RRIDAB_2801744, AB_2655506, AB_2655507, AB_2655510, AB_2655511, AB_2801753

References for CD164 Antibody, anti-human

Publications

  1. Forde, S. et al. (2007)
    Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133
    +
    cells
    Blood 109: 1825-1833
  2. Zannettino, A. C. et al. (1998) The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis. Blood 92(8): 2613-2628
  3. Huang, A. F. et al. (2013) CD164 regulates the tumorigenesis of ovarian surface epithelial cells through the SDF-1α/CXCR4 axis. Mol. Cancer 12(1): 115-115

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