Clone:
REA377
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Fc-gamma-RIIB, FCGR3, FcRIII, FcR-10, Fc-gamma RII, FcRII, Ly-17

Specifications for CD16/CD32 Antibody, anti-mouse, REAfinity™

Overview

Clone REA377 recognizes a shared epitope common to the human CD16 and CD32 antigens. CD16 and CD32 are also known as FcγIII and FcγII, respectively, and bind to epitopes located in the constant region domain of IgG. CD16 and CD32 are predominantly expressed on cells of hematopoietic lineages, including B cells, monocytes, NK cells, granulocytes, and dendritic cells. They are also found on hematopoietic progenitor cells, where they appear to play a role in T and B cell development.
Additional information: Clone REA377 displays negligible binding to Fc receptors.

Alternative names

Fc-gamma-RIIB, FCGR3, FcRIII, FcR-10, Fc-gamma RII, FcRII, Ly-17

Detailed product information

Technical specifications

CloneREA377
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD16/CD32
Alternative names of antigenFc-gamma-RIIB, FCGR3, FcRIII, FcR-10, Fc-gamma RII, FcRII, Ly-17
Molecular mass of antigen [kDa]26; 33
Distribution of antigenB cells, monocytes, NK cells, granulocytes, dendritic cells
Entrez Gene ID14131, 14130
RRIDAB_2752043, AB_2655424, AB_2655425, AB_2655428, AB_2655429, AB_2752054

References for CD16/CD32 Antibody, anti-mouse, REAfinity™

Publications

  1. de Andrés, B. et al. (1997) Fc gammaRII (CD32) is linked to apoptotic pathways in murine granulocyte precursors and mature eosinophils. Blood 90(3): 1267-1274
  2. de Andrés, B. et al. (1998) A regulatory role for Fcgamma receptors CD16 and CD32 in the development of murine B cells. Blood 92(8): 2823-2829
  3. Zhang, D. et al. (2014) CD16 inhibition increases host survival in a murine model of severe sepsis. J. Surg. Res. 187(2): 605-609

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CD16/CD32 Antibody, anti-mouse, REAfinity™

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