Clone:
DX27
Type of antibody:
Primary antibodies
Isotype:
mouse IgG2aκ
Applications:
FC
Alternative names:
KIR2DL2, KIR2DL3

Specifications for CD158b (KIR2DL2/DL3) Antibody, anti-human

Overview

Clone DX27 reacts with CD158b1 (KIR2DL2), CD158b2 (KIR2DL3), and CD158j (KIR2DS2), members of the killer immunoglobulin-like receptor (KIR) family expressed on natural killer (NK) cells and subsets of T cells.
KIRs contribute to the regulation of NK cell–mediated cytotoxicity and possess high allelic polymorphism with either 2 or 3 Ig-like extracellular domains. According to the length of their cytoplasmic tail, KIRs can be further subdivided in inhibitory KIRs (KIR2DL or KIR3DL) and activating KIRs (KIR2DS or KIR3DS). CD158b provides an inhibitory signal on NK cell lytic activity upon interaction with HLA C (e.g. alleles HLA-Cw1, HLA-Cw3, HLA-Cw7) in an antigen-independent manner.

Alternative names

KIR2DL2, KIR2DL3

Detailed product information

Technical specifications

CloneDX27
Clonalitymonoclonal
Isotypemouse IgG2aκ
Isotype controlIsotype Control Antibody, mouse IgG2a
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD158b (KIR2DL2/DL3)
Alternative names of antigenKIR2DL2, KIR2DL3
Molecular mass of antigen [kDa]35-36
Distribution of antigenNK cells, T cells
Entrez Gene ID3803
RRIDAB_2660192, AB_871610, AB_2660193, AB_871609, AB_2660195, AB_2660196, AB_871608

Resources for CD158b (KIR2DL2/DL3) Antibody, anti-human

References for CD158b (KIR2DL2/DL3) Antibody, anti-human

Publications

  1. Farag, S. S. et al. (2002) Natural killer cell receptors: new biology and insights into the graft-versus-leukaemia effect. Blood 100(6): 1935-1947
  2. Hsu, K. et al. (2002) The killer cell immunoglobin-like (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunol. Rev. 190: 40-52
  3. Selvakumar, A. et al. (1997) Polymorphism and domain variability of human killer cell inhibitory receptors. Immunol. Rev. 155: 183-196

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