Clone:
REA984
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CTLA-4, CTLA4, Ly-56

Specifications for CD152 Antibody, anti-mouse, REAfinity™

Overview

Clone REA984 recognizes the mouse CD152 antigen, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4), which is a 33 kDa member of the immunoglobin superfamily and is expressed on activated T cells at a low level. CTLA-4 and CD28 have similarities concerning B7 family counter-receptors. While CD28 delivers a co-stimulary signal in T cell activation, CD152 restricts the progression of T cells to an activated state by inhibiting interleukin 2 (IL-2) secretion and cellular proliferation. A large proportion of CTLA-4 is intracellular localized. For a complete detection it may be necessary to assess intracellular staining in addition to surface expression of CD152.
Additional information: Clone REA984 displays negligible binding to Fc receptors.

Alternative names

CTLA-4, CTLA4, Ly-56

Detailed product information

Technical specifications

CloneREA984
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD152
Alternative names of antigenCTLA-4, CTLA4, Ly-56
Molecular mass of antigen [kDa]21
Distribution of antigenB cells, lymphocytes, T cells
Entrez Gene ID12477
RRIDAB_2727553, AB_2727510, AB_2727554, AB_2727511, AB_2727555, AB_2727512, AB_2727552

References for CD152 Antibody, anti-mouse, REAfinity™

Publications

  1. June, C. H. et al. (1994) The B7 and CD28 receptor families. Immunol. Today 15(7): 321-331
  2. Walunas, T. L. et al. (1994) CTLA-4 can function as a negative regulator of T cell activation. Immunity 1(5): 405-413
  3. Krummel, M. F. and Allison, J. P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182(2): 459-465

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