Clone:
REA697
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
MCAM, 1-gicerin, MUC18, S-endo, s-gicerin, Endo-CAM, Mel-CAM

Specifications for CD146 (LSEC) Antibody, anti-rat, REAfinity™

Overview

Clone REA697 recognizes the rat CD146 (LSEC) antigen, also known as Gicerin, MCAM, MUC18, or MEL-CAM. CD146 is a putative cell adhesion molecule of an immunoglobulin (Ig) superfamily which shows homophilic and heterophilic binding activities with two isoforms: S-gicerin, which has small cytoplasmic domain and the same extracellular domain as l-gicerin, shows stronger cell adhesion activity. CD146 is expressed on endothelial cells and a variety of tumor cells and is involved in cell adhesion and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. In rat, neurite promotion activity of CD146 from hippocampal neurons is reported.
Additional information: Clone REA697 displays negligible binding to Fc receptors.

Alternative names

MCAM, 1-gicerin, MUC18, S-endo, s-gicerin, Endo-CAM, Mel-CAM

Detailed product information

Technical specifications

CloneREA697
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesrat
AntigenCD146 (LSEC)
Alternative names of antigenMCAM, 1-gicerin, MUC18, S-endo, s-gicerin, Endo-CAM, Mel-CAM
Molecular mass of antigen [kDa]69
Distribution of antigenendothelial cells, tumor cells, neurons
Entrez Gene ID78967
RRIDAB_2655171, AB_2655172, AB_2655173, AB_2655174, AB_2655175, AB_2655170

References for CD146 (LSEC) Antibody, anti-rat, REAfinity™

Publications

  1. Taira, E. et al. (2004) Characterization of Gicerin/MUC18/CD146 in the rat nervous system. J. Cell. Physiol. 198(3): 377-387

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CD146 (LSEC) Antibody, anti-rat, REAfinity™

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