Clone:
HTF-1
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
F3, Tissue Factor (TF), TF, TFA, CD142

Specifications for CD142 Antibody, anti-human

Overview

The monoclonal antibody HTF-1 recognizes the 45 kDa type I transmembrane glycoprotein also known as TF (tissue factor). It functions as the high-affinity receptor for the coagulation factor VII and enables cells to initiate the blood coagulation cascades. It is reported, that the tissue factor exists in a membrane-bound and in a soluble form. It is expressed on activated endothelial cells and on monocytes, macrophages, and platelets, which are stimulated with inflammatory mediators such as LPS or TNF alpha. CD142 is also present on some tumor cells such as lung, breast, pancreatic, and colon, and on non-immune-tissues.

Alternative names

F3, Tissue Factor (TF), TF, TFA, CD142

Detailed product information

Technical specifications

CloneHTF-1
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD142
Alternative names of antigenF3, Tissue Factor (TF), TF, TFA, CD142
Molecular mass of antigen [kDa]30
Distribution of antigenendothelial cells, epithelial cells, fibroblasts, monocytes, ES and iPS cells, liver, pancreas, spleen
Entrez Gene ID2152
RRIDAB_2655127, AB_2655128, AB_2655129, AB_2655130, AB_2655131, AB_2655132, AB_2655133, AB_2655134, AB_2655135, AB_2655136, AB_2655137, AB_2655138, AB_2655139, AB_2655140, AB_2655141, AB_2655142, AB_2655143, AB_2655126

References for CD142 Antibody, anti-human

Publications

  1. Carson, S. D. et al. (1994) Fibroblast tissue factor: calcium and ionophore induce shape changes, release of membrane vesicles, and redistribution of tissue factor antigen in addition to increased procoagulant activity. Blood 84: 526-534
  2. Bogdanov, V. Y. et al. (2003) Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat Med 9: 458-462
  3. Butenas, S. et al. (2008) Tissue factor activity and function in blood coagulation. Thromb. Res. 122: S42-S46
  4. Golino, P. et al. (2002) The inhibitors of the tissue factor: factor VII pathway. Thromb. Res. 106(3): V257-V265

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