Clone:
REA628
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
PDGF-R-beta, PDGFR-beta, PDGFR-1, AI528809, Pdgfr

Specifications for CD140b pY857 Antibody, anti-mouse, REAfinity™

Overview

Clone REA628 recognizes the mouse CD140b antigen phosphorylated at tyrosine 857 (pY857). CD140b is a single-pass type I membrane protein also known as platelet-derived growth factor receptor beta (PDGFR-beta). PDGFR is composed of PDGFRα (CD140a) and/or PDGFRβ (CD140b) molecules. CD140b is broadly expressed in embryonic tissue and in cells of mesodermal origin, in adult tissue as fibroblasts, smooth muscle cells, glial cells, and chondrocytes. It is a tyrosine-protein kinase and receptor dimerization and transphosphorylation at tyrosine residues activates the intracellular kinase activity. CD140b plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis, and migration.
Additional information: Clone REA628 displays negligible binding to Fc receptors.

Alternative names

PDGF-R-beta, PDGFR-beta, PDGFR-1, AI528809, Pdgfr

Detailed product information

Technical specifications

CloneREA628
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse, human
Cross-reactivityhuman
AntigenCD140b pY857
Alternative names of antigenPDGF-R-beta, PDGFR-beta, PDGFR-1, AI528809, Pdgfr
Molecular mass of antigen [kDa]120
Distribution of antigenchondrocytes, fibroblasts, smooth muscle
Entrez Gene ID18596
RRIDAB_2655105, AB_2655106, AB_2655107, AB_2655104

References for CD140b pY857 Antibody, anti-mouse, REAfinity™

Publications

  1. Gao, B. B. et al. (2006) Angiotensin II stimulates phosphorylation of an ectodomain-truncated platelet-derived growth factor receptor-beta and its binding to class IA PI3K in vascular smooth muscle cells. Biochem. J. 397(2): 337-344
  2. Fiaschi, T. et al. (2003) Down-regulation of platelet-derived growth factor receptor signaling during myogenesis. Cell. Mol. Life Sci. 60(12): 2721-2735
  3. Getachew, R. et al. (2010) PDGF beta-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL. Endocrinology 151(9): 4356-4367

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