Clone:
TKS-1
Type of antibody:
Primary antibodies
Isotype:
rat IgG2aκ
Applications:
FC
Alternative names:
TNFSF9, 4-1BBL, Ly63l

Specifications for CD137L (4-1BBL) Antibody, anti-mouse

Overview

Clone TKS-1 recognizes the mouse CD137L antigen, a Single-pass type II membrane protein also known as 4-1BB ligand (4-1BBL) or Tumor necrosis factor ligand superfamily member 9 (Tnfsf9). CD137L is expressed on activated APC and plays an essential role in regulating adaptive immune responses. Its receptor, 4-1BB is an inducible costimulatory member of the tumor necrosis factor receptor family expressed on activated CD4 and CD8 T cells. 4-1BB can enhance both the proliferation and the survival of murine CD4 and CD8 T cells. Recent evidence in mouse models suggests that 4-1BB/CD137L interaction plays an important role in the memory CD8 T cell response to viruses.

Alternative names

TNFSF9, 4-1BBL, Ly63l

Detailed product information

Technical specifications

CloneTKS-1
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD137L (4-1BBL)
Alternative names of antigenTNFSF9, 4-1BBL, Ly63l
Molecular mass of antigen [kDa]34
Distribution of antigenT cells
Entrez Gene ID21950
RRIDAB_2655009, AB_2655010, AB_2655011, AB_2655012, AB_2655015, AB_2655016, AB_2655017, AB_2655018, AB_2655019, AB_2655020

References for CD137L (4-1BBL) Antibody, anti-mouse

Publications

  1. Goodwin, R. G. et al. (1993) Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur. J. Immunol. 23(10): 2631-2641
  2. Wang, C. et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol. Rev. 229(1): 192-215
  3. Ma, J. et al. (2013) The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation. Sci Signal 6(295): ra87

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