Clone:
REA680
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
IL-7R, IL-7Rα, IL-7Ralpha

Specifications for CD127 Antibody, anti-mouse, REAfinity™

Overview

Clone REA680 recognizes the mouse antigen CD127, also known as IL-7 receptor α chain (IL-7Rα). Mouse CD127 is a 60–90 kDa type I transmembrane glycoprotein. It is a component of the high affinity IL-7 receptor (IL-7R) and the receptor for thymic stromal lymphopoietin (TSLP). CD127 is expressed on immature B cells, CD4
-
CD8
-
, CD4
+
, and CD8
+
thymocytes, naive and memory T cells, thymic NK cells, and bone marrow stromal cells. Upon activation of naive T cells, CD127 expression is downregulated. Re-expression of CD127 identifies the effector cells that will differentiate into memory T cells.
Additional information: Clone REA680 displays negligible binding to Fc receptors.

Alternative names

IL-7R, IL-7Rα, IL-7Ralpha

Detailed product information

Technical specifications

CloneREA680
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD127
Alternative names of antigenIL-7R, IL-7Rα, IL-7Ralpha
Molecular mass of antigen [kDa]50
Distribution of antigenB cells, T cells, monocytes, lymphocytes, thymocytes, bone marrow, liver
Entrez Gene ID16197
RRIDAB_2783928, AB_2654845, AB_2654846, AB_2751849

References for CD127 Antibody, anti-mouse, REAfinity™

Publications

  1. Colpitts, S. L. et al. (2009)
    IL-7 receptor expression provides the potential for long-term survival of both CD62L
    high
    central memory T cells and Tʜ1 effector cells during
    Leishmania major
    infection.
    J. Immunol. 182: 5702-5711
  2. Vosshenrich, C. A. et al. (2006) A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat. Immunol. 7: 1217-1224
  3. Kaech, S. M. et al. (2003) Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4: 1191-1198
  4. Sudo, T. et al. (1993) Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 90: 9125-9129
  5. Goodwin, R. G. et al. (1990) Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell 60: 941-951

Related products for
CD127 Antibody, anti-mouse, REAfinity™

2 products available