Clone:
REA996
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
c-kit, KIT, PBT, SCFR

Specifications for CD117 Antibody, anti-human, REAfinity™

Overview

Clone REA996 recognizes the human CD117 antigen, also known as c-kit or SCF receptor. CD117 is a 145 kDa receptor tyrosine kinase involved in stem cell signaling, activation, and proliferation. It is expressed on about 1–3% of peripheral blood mononuclear cells (PBMCs) and cord blood cells and on up to 10% of bone marrow cells. CD117 is further expressed on basophils, myeloid dendritic cells, TCRα/β
+
T cells, CD19
+
B cells, and CD56
+
NK cells, as well as on mast cells, melanocytes, and acute myeloid leukemia (AML) blasts.
Additional information: Clone REA996 displays negligible binding to Fc receptor.

Alternative names

c-kit, KIT, PBT, SCFR

Detailed product information

Technical specifications

CloneREA996
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD117
Alternative names of antigenc-kit, KIT, PBT, SCFR
Molecular mass of antigen [kDa]107
Distribution of antigenB cells, endothelial cells, fibroblasts, mast cells, megakaryocytes, NK cells, red blood cells, T cells, stem cells, hematopoietic stem and progenitor cells, leukemia cells, cancer stem cells, basophils, myeloid dendritic cells, bone marrow, brain, kidney
Entrez Gene ID3815
RRIDAB_2727665, AB_2727620, AB_2727666, AB_2727621, AB_2727667, AB_2727622, AB_2727619, AB_2727664

References for CD117 Antibody, anti-human, REAfinity™

Publications

  1. Yarden, Y. et al. (1987) Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J. 6(11): 3341-3351
  2. Bühring, H. J. et al. (1991) The product of the proto-oncogene c-kit (P145c-kit) is a human bone marrow surface antigen of hematopoietic precursor cells which is expressed on a subset of acute non-lymphoblastic cells. Leukemia 5: 854-860
  3. Guth, S. et al. (1995) Immunomagnetic isolation and surface phenotyping of human c-kit receptor-expressing cells from peripheral blood. 9th International Congress of Immunology

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