Clone:
AC126
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
c-kit, KIT, PBT, SCFR

Specifications for CD117 Antibody, anti-human

Overview

CD117, also known as c-kit or SCF receptor, is a 145 kDa receptor tyrosine kinase involved in stem cell signaling, activation, and proliferation. The CD117 antigen is expressed on about 1–3% of peripheral blood mononuclear cells (PBMCs) and cord blood cells and on up to 10% of bone marrow cells. CD117 is further expressed on basophils, myeloid dendritic cells, TCRα/β
+
T cells, CD19
+
B cells, and CD56
+
NK cells, as well as on mast cells, melanocytes, and acute myeloid leukemia (AML) blasts.

Alternative names

c-kit, KIT, PBT, SCFR

Detailed product information

Technical specifications

CloneAC126
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD117
Alternative names of antigenc-kit, KIT, PBT, SCFR
Molecular mass of antigen [kDa]107
Distribution of antigenB cells, endothelial cells, fibroblasts, mast cells, megakaryocytes, NK cells, red blood cells, T cells, stem cells, cancer stem cells, hematopoietic stem and progenitor cells, leukemia cells, bone marrow, brain, kidney, liver, lung
Entrez Gene ID3815
RRIDAB_615059, AB_2660110

References for CD117 Antibody, anti-human

Publications

  1. Bühring, H. J. et al. (1991) The product of the proto-oncogene c-kit (P145c-kit) is a human bone marrow surface antigen of hematopoietic precursor cells which is expressed on a subset of acute non-lymphoblastic cells. Leukemia 5: 854-860
  2. Guth, S. et al. (1995) Immunomagnetic isolation and surface phenotyping of human c-kit receptor-expressing cells from peripheral blood. 9th International Congress of Immunology

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