Clone:
REA1182
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
LAMP-2, Lamp2, LGP-B, Mac-3

Specifications for CD107b Antibody, anti-mouse, REAfinity™

Overview

Clone REA1182 recognizes the mouse CD107b antigen, a highly glycosylated 110 kDa single-pass type I membrane protein also known as lysosome-associated membrane protein-2 (LAMP-2) or Mac-3 antigen. It is widely located in lysosomal membranes and the plasma membrane of macrophages and some myeloid cell lines. Under certain circumstances, e.g., after platelet activation, during granulocytic differentiation and activation, in malignant carcinoma cells, and in cytotoxic T lymphocytes, it is also found at the cell surface. CD107b has been described as a receptor for the selective import and degradation of cytosolic proteins in the lysosome or chaperone-mediated autophagy.
Additional information: Clone REA1182 displays negligible binding to Fc receptors.

Alternative names

LAMP-2, Lamp2, LGP-B, Mac-3

Detailed product information

Technical specifications

CloneREA1182
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD107b
Alternative names of antigenLAMP-2, Lamp2, LGP-B, Mac-3
Molecular mass of antigen [kDa]43
Entrez Gene ID16784
RRIDAB_2783909, AB_2783912, AB_2783911, AB_2783908, AB_2783910

References for CD107b Antibody, anti-mouse, REAfinity™

Publications

  1. Cha, Y. et al. (1990) The cDNA sequence of mouse LAMP-2. Evidence for two classes of lysosomal membrane glycoproteins. J. Biol. Chem. 265(9): 5008-5013
  2. Tanaka, Y. et al. (2000) Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature 406(6798): 902-906
  3. Asaoka, Y. et al. (2013) Immunohistochemistry of LAMP-2 and adipophilin for phospholipidosis in liver and kidney in ketoconazole-treated mice. Exp. Toxicol. Pathol. 65(6): 817-823

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