Clone:
REA531
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
ITGAE, Integrin aE, HML1, Integrin E, integrin alpha E

Specifications for CD103 Antibody, anti-rat, REAfinity™

Overview

Clone REA531 recognizes the rat CD103 antigen, a type I transmembrane protein, which is also known as αE integrin. It associates with integrin β7 to form the heterodimeric integrin molecule αEβ7 and is a receptor for the ligand E-cadherin expressed on epithelial cells. CD103 is expressed by bone marrow–derived dendritic cells and is found on intraepithelial and peripheral lymphocytes, such as regulatory T cell subpopulations. Rat plasmacytoid dendritic cells do not express the dendritic cell–specific marker CD103.
Additional information: Clone REA531 displays negligible binding to Fc receptors.

Alternative names

ITGAE, Integrin aE, HML1, Integrin E, integrin alpha E

Detailed product information

Technical specifications

CloneREA531
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesrat
AntigenCD103
Alternative names of antigenITGAE, Integrin aE, HML1, Integrin E, integrin alpha E
Molecular mass of antigen [kDa]129
Distribution of antigenT cells, lymphocytes
Entrez Gene ID83577
RRIDAB_2654358, AB_2654359, AB_2654360, AB_2654361, AB_2654362, AB_2654363, AB_2654364, AB_2654357

References for CD103 Antibody, anti-rat, REAfinity™

Publications

  1. Hubert, F. X. et al. (2004)
    Rat plasmacytoid dendritic cells are an abundant subset of MHC Class II
    +
    CD4
    +
    CD11b
    OX62
    and type I IFN-producing cells that exhibit selective expression of Toll-like receptors 7 and 9 and strong responsiveness to CpG.
    J. Immunol. 172(12): 7485-7494
  2. Trinité, B. et al. (2005)
    Immature CD4
    CD103
    +
    rat dendritic cells induce rapid caspase-independent apoptosis-like cell death in various tumor and non tumor cells and phagocytose their victims.
    J. Immunol. 175: 2408-2417
  3. Cynthia, S. et al. (2002) Flt-3 ligand (FL) drives differentiation of rat bone marrow-derived dendritic cells expressing OX62 and/or CD161 (NKR-P1). J. Leukoc. Biol. 71: 941-949

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