Clone:
REA846
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Kidney cadherin, K-cadherin, KCAD, Cadherin 6

Specifications for Cadherin-6 Antibody, anti-human, REAfinity™

Overview

Clone REA846 recognizes the human cadherin-6 antigen, a type I membrane-associated glycoprotein also known as K-cadherin or KCAD, which is a member of the cadherin superfamily. Cadherin-6 is found in a high level in kidney, brain, and cerebellum. It is also expressed in renal and ovariancarcinoma and in a low level in lung, pancreas, gastric mucosa, and cytotrophoblasts. Cadherins are involved in cell adhesion, forming adherens junctions. This is mediated by extracellular domains of cadherins, whereas the intracellular cytoplasmic tail associates with different adaptor and signaling proteins.
Additional information: Clone REA846 displays negligible binding to Fc receptors.

Alternative names

Kidney cadherin, K-cadherin, KCAD, Cadherin 6

Detailed product information

Technical specifications

CloneREA846
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCadherin-6
Alternative names of antigenKidney cadherin, K-cadherin, KCAD, Cadherin 6
Molecular mass of antigen [kDa]82
Distribution of antigenother, brain, kidney, lung, ovary, pancreas
Entrez Gene ID1004
RRIDAB_2651317, AB_2651318, AB_2651319, AB_2651320, AB_2651321, AB_2651322, AB_2651323, AB_2651316

References for Cadherin-6 Antibody, anti-human, REAfinity™

Publications

  1. Shimoyama, Y. et al. (1999) Biochemical characterization and functional analysis of two type II classic cadherins, cadherin-6 and -14, and comparison with E-cadherin. J. Biol. Chem. 274(17): 11987-11994
  2. Shimoyama , Y. et al. (1999) Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. Biochem. J. 274(17): 159-167
  3. Angst, B. D. et al. (2001) The cadherin superfamily: diversity in form and function. J. Cell. Sci. 114(4): 629-641

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