Clone:
REA593
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
ADAM-TS 13, vWF-CP, VWFCP

Specifications for ADAMTS13 Antibody, anti-human, REAfinity™

Overview

Clone REA593 recognizes the human ADAMTS13 antigen, which is also known as von Willebrand factor-cleaving protease (VWFCP). ADAMTS13 is a disintegrin and metalloproteinase with a thrombospondin type 1 motif which splits the VWF multimers in plasma into smaller forms thereby controlling VWF-mediated platelet thrombus formation. ADAMTS13 is expressed in liver and secreted in blood.
Additional information: Clone REA593 displays negligible binding to Fc receptors.

Alternative names

ADAM-TS 13, vWF-CP, VWFCP

Detailed product information

Technical specifications

CloneREA593
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenADAMTS13
Alternative names of antigenADAM-TS 13, vWF-CP, VWFCP
Molecular mass of antigen [kDa]145
Distribution of antigenliver
Entrez Gene ID11093
RRIDAB_2651198, AB_2651199, AB_2651200, AB_2651197

References for ADAMTS13 Antibody, anti-human, REAfinity™

Publications

  1. Akiyama, M. et al. (2009) Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor. Proc. Natl. Acad. Sci. U.S.A. 106(46): 19274-19279
  2. Soejima, K. et al. (2001) A novel human metalloprotease synthesized in the liver and secreted into the blood: possibly, the von Willebrand factor-cleaving protease? J. Biochem. 130(4): 475-480
  3. Furlan, M. et al. (2001) Aetiology and pathogenesis of thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome: the role of von Willebrand factor-cleaving protease. Best Pract Res Clin Haematol 14(2): 437-454

Related products for
ADAMTS13 Antibody, anti-human, REAfinity™

3 products available