Research areas - Immunology - Tumor immunology

Tumor immunology

The immune system plays a crucial role in host protection against carcinogenesis by eliminating tumor cells. However, some of the tumor cells are not detected by the immune system and a variety of immunologic mechanisms contribute to tumor escape and subsequent tumor growth. Miltenyi Biotec brings you cutting-edge solutions for your tumor immunology research – from time-saving, automated tissue dissociation through fast and efficient cell separation to sophisticated flow cytometric or molecular analysis, and cell culture.

Sample preparation

Make the most of your experiments by starting with excellent sample material. Benefit from our innovative instruments and reagents for optimal sample preparation. The various MACS® Tissue Dissociation Kits in combination with the gentleMACS Dissociators and their convenient pre-set programs allow the automated preparation of single-cell suspensions from tumors and other tissues with excellent viability rates.

Download a report by Parker et al. on gentleMACS Dissociation of melanoma tumors for the generation of tumor-infiltrating lymphocyte cultures for adoptive cell therapy.

Cell separation

Immune cells located in solid tumors and tumor microenvironment as well as in other tissues can be easily isolated using MACS® Cell Separation reagents. Use the most comprehensive cell separation portfolio available to obtain your target cells, e.g., tumor-infiltrating CD4+ T helper lymphocytes. Excellent purities and full functionality of target cell populations allow an accurate and thorough characterization.

Explore our interactive poster introducing you to our cell separation tools for tumor immunology research.

Cell analysis

Miltenyi Biotec provides a large portfolio of fluorochrome-conjugated antibodies for human, mouse, rat, and non-human primate immune cells. Analyze cytokine secretion, e.g., IFN-γ, using MACS Cytokine Secretion Assay – Detection Kits and benefit from the expanding variety of marker combinations for multiparameter flow cytometry.

Cell culture

Miltenyi Biotec provides a range of growth factors and cytokines, including IL-2, which is required for the in vitro expansion of isolated tumor-infiltrating lymphocytes (TILs). MACS® and Stemgent® Media in combination with the growing portfolio of research-, premium-, and GMP-grade MACS Cytokines are a premium choice for your cell culture applications.

Viscover Imaging

The Viscover™ Product Line offers a unique range of small animal in vivo contrast agents covering the principal imaging modalities: MRI, CT, ultrasound, and optical imaging. Track tumor progression in real time or track transferred cells in vivo.

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