Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS). MS is thought to be initiated by CNS-infiltrating self-reactive T cells that recognize myelin antigens. Damage of target tissue, however, is mediated by other components of the immune system, such as antibodies, complement, CD8+ T cells, and factors produced by innate immune cells.
Download the report by Prendergast and Anderton on detection, isolation, and phenotypic stability of IL-17–producing autoreactive T cells after stimulation with their cognate peptide antigen.
Download a list of selected references on MS research