Research areas - Immunology - Autoimmunity - Multiple sclerosis

Multiple sclerosis

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS). MS is thought to be initiated by CNS-infiltrating self-reactive T cells that recognize myelin antigens. Damage of target tissue, however, is mediated by other components of the immune system, such as antibodies, complement, CD8+ T cells, and factors produced by innate immune cells.

Download the report by Prendergast and Anderton on detection, isolation, and phenotypic stability of IL-17–producing autoreactive T cells after stimulation with their cognate peptide antigen.

Download a list of selected references on MS research.

Sample preparation

Dissociation of tissue samples from the central nervous system as well as peripheral lymphoid organs is simple and can be standardized with the gentleMACS Dissociators and our various tissue dissociation kits, e.g., the Neural Tissue Dissociation Kits. The use of Myelin Removal Beads II and Pre-Separation Filters greatly improves sample quality for downstream applications.

Download our flyer on Neural Tissue Dissociation Kits.

Cell separation

Detailed studies on immune cells involved in MS development and progression require cell populations of high purity. Miltenyi Biotec provides reagents for the isolation of all relevant cell types, e.g., T cells, B cells, and CNS-resident microglia.

Cell analysis

In-depth analysis of immune cells involved in MS, such as the inflammatory CD4+IFN-γ+ or CD4+IL-17+ T cells, is easily achieved with Miltenyi Biotec’s fluorochrome-conjugated antibodies. The unique Cytokine Secretion Assay Technology allows the isolation and analysis of viable cytokine-secreting cells.
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autoMACS Pro Separator - Starter Kit

Components:
  • autoMACS Pro Separator Instrument
  • MACS MiniSampler
  • MACS Reagent Rack 4 (130-094-574)
  • Chill 5, 15, 50 Rack Set (130-097-038)
  • barcode reader
  • software
  • autoMACS® Columns (130-021-101)
  • 4×column substitute
  • autoMACS Pro Buffer Combination
  • User manual
  • short instructions
  • one-year warranty
 
130-092-545 price on request here

MACSQuant Analyzer 10

Content: 1 unit
 
130-096-343 price on request here

MACSQuant VYB

Content: 1 unit
 
130-096-116 price on request here

MultiMACS Cell24 Separator Plus

Components:
  • MultiMACS Cell24 Separator
  • MACS Elution Station
  • Elution Chamber Base
  • Elution Chamber Lid I
  • Elution Chamber Lid II
  • Multi-24 Column Block (130-095-692)
  • 2×24-well Deep Well Plate
  • Single-Column Adapter
  • MultiMACS 5 mL Tube Rack (130-095-331)
  • Column Blank Holder and 9 Column Blanks
  • Tubing
  • Power cord
  • Null modem cable
  • High power CAN cable
 
130-098-637 price on request here

21 CFR Part 11 compliant MACSQuantify V2.10 additional PC license

130-112-559 price on request here

21 CFR Part 11 compliant setup of MACSQuantify V2.10

160-002-148 price on request here

24-well Deep Well Plates

Content: 4 pieces (1)

Packing unit

(1)sterile packaged
 
130-110-500 $45.00

Adipose Tissue Progenitor Isolation Kit, mouse

Capacity: for up to 1×108 total cells
 
130-106-639 $435.00

Annexin V MicroBead Kit

Capacity: for 1×109 total cells
 
130-090-201 $700.00

Anti-BP-1 (Ly-51)-FITC, mouse

For research use only
Content: 30 µg in 1 mL (1)

Quantity

(1)200 tests. One test corresponds to labeling of up to 106 cells in a final volume of 50 µL.
 
130-102-170 $40.00
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