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Data gallery for MRI

Atherosclerosis imaging GadoSpin F
GadoSpin™ F for atherosclerosis and vascular imaging
GadoSpin™ F is a unique MRI agent developed for atherosclerosis imaging. It contains a hydrophobic targeting moiety for high protein binding affinity. The agent accumulates in atherosclerotic plaques and enables direct T1-weighted visualization of plaque burden. Accumulation of GadoSpin F in WHHL rabbit atherosclerotic plaque is measured by T1-weighted MRI (TFL IR, 1.5T) 6 hours (left) and 24 hours (right) after injection. 24 hours after injection of GadoSpin F, the majority of the contrast agent had cleared from the blood, but the plaque burden is enhanced.
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MR Angiography GadoSpin P
GadoSpin™ P MR angiography
GadoSpin™ P is a long-circulating imaging agent for magnetic resonance angiography (MRA). It is based on a high molecular weight polymer that does not extravasate from intact blood vessels. Whole-body T1-weighted MR angiography of a mouse injected with GadoSpin P reveals vascular fine structure.
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DCE imaging GadoSpin D
GadoSpin™ D dynamic contrast enhanced imaging
GadoSpin™ D is a unique dendritic MRI agent for studying blood vessel integrity and angiogenesis in tumors and inflamed tissues via dynamic contrast-enhanced (DCE) MRI. It contains 24 gadolinium ions in a globular structure. DCE-MRI-based tumor therapy monitoring using GadoSpin D. The effect of antiangiogenic treatment in mice is studied as contrast agent uptake in regions of tumor angiogenesis. Comparing T1-weighted pre- and post-contrast scans, the contrast effect appears to be significantly lower (and restricted to the cortex region) in treated mice as compared to control mice. This can be attributed to a treatment-induced reduction of neovasculature.
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Blood brain barrier GadoSpin M
GadoSpin™ M brain tumor progression
GadoSpin™ M is an all-purpose extracellular gadolinium chelate agent for classical contrast-enhanced MRI and for studying CNS disease. Intracranial tumor in mouse exhibits contrast enhancement after GadoSpin M has passed the compromised blood-brain barrier. The image series shows tumor progression.
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Liver imaging FeraSpin R
FeraSpin™ R for liver imaging

FeraSpin™ R is a proven superparamagnetic iron oxide (SPIO) agent that consists of nanoparticles from 10–90 nanometers. It delivers optimal T2/T2* contrast and is rapidly taken up by liver and spleen macrophages. FeraSpin R accumulates in mouse liver Kupffer cells, leading to T2* hypointensity of healthy liver tissue and rendering the tumor white and highly visible.

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Angiography FeraSpin XS
FeraSpin™ XS for MR angiography
FeraSpin™ XS is an ultra-small superparamagnetic iron oxide (USPIO) nanoparticle agent for MR angiography (MRA). It has been size-selected from FeraSpin R and is part of the FeraSpin Series. FeraSpin XS has the longest circulation time of the entire FeraSpin product family and can be imaged by both T1 (positive contrast) and T2/T2*-weighted sequences. Mouse whole-body T1-weighted MR angiography using FeraSpin XS: USPIO –enhanced (18nm hydrodynamic particle size) MR angiographic images acquired after FeraSpin XS application.
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Liver imaging FeraSpin Series
FeraSpin™ Series tunable MRI contrast

FeraSpin™ Series is a product family of six size-selected agents derived from FeraSpin R: FeraSpin XS to FeraSpin XXL. The identical chemical composition and ultra-narrow size distribution of these fractions allow for fine-tuning of the pharmacologic profile according to your own innovative applications. This unique series of size-selected superparamagnetic iron oxide nanoparticles encompasses particle fractions ranging from ultrasmall to a large size, that offers tunable T1 and T2/T2* relaxation properties FeraSpin XS, M, and XL (top to bottom) accumulated in mouse liver Kupffer cells leading to T2* hypointensity of healthy liver tissue (left column: pre-contrast, right column: 30 min. post injection). Accumulation and T2* effect clearly increase with particle size.

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Cell tracking in vivo FeraTrack
FeraTrack™ for cell tracking in vivo

The new FeraTrack™ Tracking Kit simplifies intracellular labeling of cells ex vivo. Cells labelled with FeraTrack can then be tracked in recipient animals using Magnetic Resonance Imaging (MRI). Visualizing neuronal progenitors intracellularly labeled with FeraTrack. Left: In vitro neuronal progenitors labeled intracellularly with FeraTrack (anti-dextran immunofluorescence). Right: In vivo MRI imaging of mouse cortex: PSA-NCAM+ cells labeled intracellularly with FeraTrack were grafted into the cortex of a mouse. A strong contrast was detected for the FeraTrack labeled cells in the left cortex at 7 Tesla MRI. (Courtesy of Prof. M. Hoehn, Max Planck Institute for Neurological Research, Cologne, Germany)

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Poster download for FeraTrack
Intracellular labeling of multiple cell types for MRI-based in vivo cell tracking

This poster, presented at the ISSCR 20111 Congress in Toronto, Canada, describes the development of the FeraTrack™ two-component tool that can be used for intracellular labeling of cells with superparamagnetic nanoparticles. Highly effective intracellular labeling of cell lines, as well as tissue-derived stem or progenitor cells, has no effect on cellular characteristics such as their differentiation potential. As proven by in vitro and in vivo MRI analysis, magnetic labelling generates strong T1 and T2*-weighted contrast images allowing for efficient and reliable cell detection and tracking.

 

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Miltenyi Biotec Inc.
Phone: +1 800 FOR MACS
Fax:+1 877 591 1060
macs@miltenyibiotec.com
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