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Data gallery for CT

Angiography ExiTron U and V
ExiTron™ U and ExiTron V extracellular CT agents for angiography
The ExiTron™ U and ExiTron V Contrast Agents have been developed as reference contrast agents for maximum convenience. ExiTron U is a classical monomeric non-ionic extracellular CT contrast agent for CT angiography (CTA) and is based on the proven iopromide agent that has long been used in human clinical practice. ExiTron V is the dimeric counterpart to ExiTron U, is based on iodixanol and has been adapted for animal imaging. CT angiography of mouse neck vasculature after injection of ExiTron U (left) and ExiTron V (right)
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CT angiography ExiTron P
ExiTron™ P CT angiography agent for renal excretion
ExiTron™ P is a long-circulating polymeric agent for high-resolution CT angiography (CTA). Comprised of a high molecular weight organic polymer, ExiTron P assures long circulation and acquisition times enabling the visualization of vascular fine structure with ease. Whole-body CT angiography in mouse using ExiTron P visualizes the heart and the abdominal vasculature in great detail.
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Liver metastases ExiTron nano 6000
ExiTron™ nano 6000: CT imaging of liver and liver metastasis
ExiTron™ nano 6000 is an innovative nanoparticle agent for spleen imaging, liver imaging, the detection of liver tumors and metastases. It is quickly phagocytosed by Kupffer cells and allows hepatic visualization for several weeks after injection. Progression of mouse liver metastases over the period of 14 days monitored in micro-CT following a single administration of ExiTron nano 6000. The individual lobes of the liver tissue appear clearly opacified.
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Angiography ExiTron nano 12000
ExiTron™ nano 12000 CT angiography agent
ExiTron™ nano 12000 is an innovative nanoparticle agent for CT angiography, liver imaging, and the detection of liver tumors and metastases. As the concentrated counterpart to ExiTron nano 6000, ExiTron nano 12000 has been optimized for high-resolution CT angiography. Volume-rendered CT angiography in mouse using ExiTron nano 12000. The inferior vena cava and the renal vascular tree are clearly visible.
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Heart ventricle system ExiTron nano 6000
ExiTron™ nano 6000 heart ventricular CT imaging
Balb/c mice were injected using 200µl ExiTron™ nano 6000 and whole body scans were performed for 15min – 60min post injection using Siemens Inveon CT scanner („med scan“, ca. 25 µm Resolution, bin-2). Coronary slices (middle) visualize clearly the ventricular system with Truncus brachiocephalicus, the Subclavian artery (A. subclavia) and left jugular artery (A. carotis communis sinster). Sagittal scan of the mouse shows clearly the details of the middle liver vein (V. hepatica media) including their branching into the periphery. (Courtesy of Dr. S. Hermann & Prof. Schäfers from EIMI, University of Münster, Germany)
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Renal parenchyma ExiTron nano 6000
ExiTron™ nano 6000 kidney ventricular CT imaging
Balb/c mice were injected using 200µl ExiTron™ nano 6000 and whole body scans were performed for 15min – 60min post injection using Siemens Inveon CT scanner („med scan“, ca. 25 µm Resolution, bin-2). Coronary slices (middle) visualize clearly the lower inferior vena cava with the left and right renal vein as well as the microvessels of renal parenchyma. The sagittal scan shows again clearly the lower inferior vena cava and the visceral artery (A. mesenterica superior). In both scans the retroorbital venous plexus of the eyes is clearly detectable. (Courtesy of Dr. S. Hermann & Prof. Schäfers from EIMI, University of Münster, Germany)
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Brain vasculature ExiTron nano 6000
ExiTron™ nano 6000 brain vascular system
Balb/c mice were injected using 200µl ExiTron™ nano 6000 and whole body scans were performed for 15min – 60min post injection using Siemens Inveon CT scanner („med scan“, ca. 25 µm Resolution, bin-2). The sagittal scan reveals clearly the brain vascular system (right). (Courtesy of Dr. S. Hermann & Prof. Schäfers from EIMI, University of Münster, Germany)
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Liver and spleen ExiTron nano 6000
ExiTron™ nano 6000 liver and spleen CT imaging
Balb/c mice were injected using 200µl ExiTron™ nano 6000 and whole body scans were performed for 15min – 60min 48h post injection using Siemens Inveon CT scanner („med scan“, ca. 25 µm Resolution, bin-2). Whole-body CT scan visualizes the liver and spleen in detail after 48h post injection. (Courtesy of Dr. S. Hermann & Prof. Schäfers from EIMI, University of Münster, Germany)
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Beating heart axial ExiTron nano 12000
ExiTron™ nano 12000 mouse vascular system: beating heart
Mice were injected with ExiTron™ nano 12000 and whole body scans were performed for 60min post injection. (Courtesy of Prof. Dr. Marc Kachelrieß, DKFZ, Heidelberg, Germany)
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Beating heart coronal ExiTron nano 12000
ExiTron™ nano 12000 mouse vascular system: beating heart
Mice were injected with ExiTron™ nano 12000 and whole body scans were performed for 60min post injection. (Courtesy of Prof. Dr. Marc Kachelrieß, DKFZ, Heidelberg, Germany)
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Beating heart (sagittal) ExiTron nano 12000
ExiTron™ nano 12000 mouse vascular system: beating heart
Mice were injected with ExiTron™ nano 12000 and whole body scans were performed for 60min post injection. (Courtesy of Prof. Dr. Marc Kachelrieß, DKFZ, Heidelberg, Germany)
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Beating heart (rendered) ExiTron nano 12000
ExiTron™ nano 12000 mouse vascular system: beating heart
Volume rendered CT angiography of the mouse thorax for visualization of heart, thoracic bone, and the superior vena cava. Mice were injected with ExiTron™ nano 12000 and whole body scans were performed for 60min post injection. (Courtesy of Prof. Dr. Marc Kachelrieß, DKFZ, Heidelberg, Germany)
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Mouse whole body (axial) ExiTron nano 12000
ExiTron™ nano 12000 mouse whole body
ExiTron™ nano 12000 mouse whole body mice were injected with Exitron nano 12000 and a transverse scan of the whole body was performed for 60min post injection. (Courtesy of Prof. Dr. Marc Kachelrieß, DKFZ, Heidelberg, Germany)
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Mouse whole body (coronal) ExiTron nano 12000
ExiTron™ nano 12000 mouse whole body
Mice were injected with ExiTron™ nano 12000 and a coronal scan of the whole body was performed for 60min post injection. (Courtesy of Prof. Dr. Marc Kachelrieß, DKFZ, Heidelberg, Germany)
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Mouse whole body (sagittal) ExiTron nano 12000
ExiTron™ nano 12000 mouse whole body
Mice were injected with ExiTron™ nano 12000 and a sagittal scan of the whole body was performed for 60min post injection. (Courtesy of Prof. Dr. Marc Kachelrieß, DKFZ, Heidelberg, Germany)
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Specificity of CT contrast agents
In vivo evaluation of CT contrast agents – a study of efficacy and specific organ uptake

J.G. Mannheim, T. Schlichthärle, and B.J. Pichler Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, Department of Preclinical Imaging and Radiopharmacy, University of Tübingen, Germany. This poster was presented at the WMIC 2011 in San Diego. Mannheim et al. presented the results of different commercial available CT contrast agents with regard to their signal enhancement in different organs.

 

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Quantification of vascular density
Quantification of vascular density through in vivo micro-computed tomography

This poster was presented at the WMIC 2011 in San Diego. Nebuloni et al. presented a new method based on in vivo micro-computed tomography for vascular density map. (Kindly provided by Prof. Dr. R. Müller, ETH Zürich, Switzerland)

 

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Time course of CT contrast enhancement
Time-course of CT contrast enhancement by two novel nanoparticle-based contrast agents in comparison to eXIA T160 in normal mice and mice with hepatocellular carcinoma

This poster was presented at the WMIC 2011 in San Diego. Apostolova et al. presented the contrast enhancement of nanoparticulated contrast agents in mice with hepatocellular carcinoma. (Kindly provided by Dr. Apostolova & Prof Dr. W. Brenner, Charite Berlin, Germany)

 

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Lung, chest and head imaging
Thorax and head CT scan using ExiTron™ nano 6000

CT Imaging of mice with ExiTron™ nano 6000 obtained with LCT-200(Hitachi Aloka Medical, Ltd.). (Courtesy of Dr. Kaori KISHIMOTO, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Japan)

 

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Vascular, liver, kidney and spleen imaging
CT scan of kidney, liver and spleen in mouse

CT Imaging of mice with ExiTron™ nano 12000 obtained with LCT-200(Hitachi Aloka Medical, Ltd.). (Courtesy of Dr. Natsuko KAWANO, Dr. Yuki TAKEZAWA, Dr. Kenji MIYAKO, Department of Reproductive Biology, National Center of Child Health and Development, Japan)

 

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