Products and Services - MACS Cell Culture and Stimulation - Stimulation reagents - Functional grade antibodies - Anti-FcεRIα antibodies – functional grade, mouse

Anti-FcεRIα antibodies – functional grade, mouse (clone: MAR-1)

Overview

Clone MAR-1 detects the alpha subunit of the murine high-affinity Fc receptor for IgE. The receptor is composed of one alpha, one beta, and two disulfid-linked gamma subunits, of which the alpha subunit binds IgE1. FcεRIα is expressed on mast and basophilic cells and is up-regulated in the presence of IgE2,3. The FcεRI complex plays an important role in triggering IgE-mediated allergic reactions.

Applications

The Anti-FcεRIα pure - functional grade antibody is suited for functional assays, for example, blocking of receptor-ligand binding.

Technical data


Antigen FcεRIα
Clone MAR-1
Isotype hamster IgG
Isotype control
Alternative names of antigen FCER1A, FcERI, Fce1a, Fcr-5
Entrez Gene ID 14125
Molecular mass of antigen [kDa] 26
Cross-reactivity
Distribution of antigen
Endotoxin level
Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
Product format Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
Fixation
Storage Store protected from light at 2–8 °C. Do not freeze.
Available conjugates pure

Library

Selected references

  1. Metzger, H. et al. (1989) The receptor with high affinity for IgE. Ciba Found. Symp. 147: 93–113.
  2. Yamaguchi, M. et al. (2001) Regulation of mouse mast cell surface Fc epsilon RI expression by dexamethasone. Int. Immunol. 13: 843–851.
  3. Kojima, T. et al. (2007) Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner. J. Immunol. 179: 7093–7100.

Product Order no. Price

Anti-FcεRIα pure – functional grade, mouse (clone: MAR-1)

For research use only
Content: 100 µg in 1 mL
 
Data sheet
130-096-083 $105.00

Customer login

Go

Forgot password?
Register for account

0 Shopping cart

Contact

Miltenyi Biotec Inc.
Phone: +1 800 FOR MACS
Fax:+1 877 591 1060
macs@miltenyibiotec.com
Contact overview

Product finder

Antibody panel builder

Toolbox

Loading...

GMP Cytokines

MACS GMP Products

Change country

Please select your country to continue