FeraTrack Direct MRI contrast agents

Overview

Magnetic resonance imaging (MRI) is the most frequently used technique for serial in vivo cell tracking applications due to high resolution of soft tissues, which makes it especially useful for imaging of the brain, muscles, or the heart.¹ In order to improve detectability of transplanted cells and produce a strong contrast against surrounding tissue, intracellular labeling of cells with iron oxide particles before transplantation has been described.² FeraTrack Direct Contrast Particles are SPIO nanoparticles specifically formulated for direct uptake from cell culture medium without the need of transfection reagent. Uptake of FeraTrack Direct Contrast Particles was proven by Prussian Blue staining, MRI, and electron microscopy. Biocompatibility was assured by cell expansion and differentiation assays of intracellularly labeled cells. Once within cells, SPIOs can induce decreased signal intensity on T1, T2, and T2*-weighted images.³

Details

Applications

FeraTrack Direct Contrast Particles are optimized for in vitro labeling of cell lines (e.g. NIH-3T3, Jurkat), primary cells (e.g. T cells), and stem cells (e.g. mesenchymal stem cells) independent of an additional transfection reagent.

Library

Selected references

  1. Hoehn, M. et al. (2007) Cell tracking using magnetic resonance imaging. J. Physiol. 584: 25–30.
  2. Rogers, W.J. et al. (2006) Technology insight: in vivo cell tracking by use of MRI. Nat. Clin. Pract. Cardiovasc. Med. 10: 554–562.
  3. Bulte, J.W. and Kraitchman, D.L. (2004) Iron oxide MR contrast agents for molecular and cellular imaging. NMR Biomed 17: 484–499.

Product Order no. Price

FeraTrack Direct MRI contrast agent

Capacity: for 5×106 total cells
 
Data sheet
130-104-185 $195.00

FeraTrack Direct MRI contrast agent

Capacity: for 25×106 total cells
 
Data sheet
130-104-186 $840.00

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Miltenyi Biotec Inc.
Phone: +1 800 FOR MACS
Fax:+1 877 591 1060
macs@miltenyibiotec.com
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