Clinical applications - Immunotherapy - NK cells

NK cells

  • Versatile – Customized strategies for manufacturing of NK cell products
  • Convenient – CliniMACS® System in combination with MACS® GMP Products
  • Promising – Anti-tumor and -infection responses reported in numerous publications
Natural killer (NK) cells are major players of the innate immune system. They play a central role in immune surveillance and early immune responses to cancer and infection.
NK cells might be explored as a tool for treatment of malignant disease in both transplant and non-transplant settings.

The use of specific CliniMACS® Product Lines allows GMP-compliant manufacturing of NK cell products according to the needs given by a specific treatment concept.

Highly enriched NK cell products are generated by CD3 depletion followed by CD56 enrichment. A combined NK cell and natural killer T (NKT) cell product is produced by a single CD56 enrichment step. Heterogeneous NK cell products can be manufactured by either CD3 or TCRα/β depletion, optionally in combination with CD19 depletion if B cell depletion is required. The latter two manufacturing strategies for NK cells allow co-enrichment of NK cells and accessory cells, such as monocytes and dendritic cells (DCs). In case of TCRα/β depletion, γ/δ T cells are also preserved within the NK cell product, and, potentially, this could have a clinical add-on value. 


References
Find products in CliniMACS Reagents
36 products available


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CliniMACS Anti-Biotin MicroBeads

Regulatory status: For research use only, not for use in humans
Availability: worldwide (3)
Content: 7.5 mL

Availability

(3)For availability in your country please contact your local representative.
 
130-019-201 $2,750.00

CliniMACS Anti-Biotin Reagent

Availability: Europe (1), USA (2), other (3)
Content: 7.5 mL

Availability

(1)In the EU, the CliniMACS System components are available as CE-marked medical devices for their respective intended use, unless otherwise stated.
(2)In the US, the CliniMACS CD34 Reagent System, including the CliniMACS Plus Instrument, CliniMACS CD34 Reagent, CliniMACS Tubing Sets TS and LS, and the CliniMACS PBS/EDTA Buffer, is FDA approved. All other products of the CliniMACS Product Line are available for use only under an approved Investigational New Drug (IND) application or Investigational Device Exemption (IDE).
(3)For availability in your country please contact your local representative.
 
173-01 price on request here

CliniMACS CD1c (BDCA-1)-Biotin for Research Use

Regulatory status: For research use only, not for use in humans
Availability: worldwide (2)
Content: 5 mL

Availability

(2)For availability in your country please contact your local representative.
 
130-025-501 $2,750.00

CliniMACS CD3 MicroBeads

Regulatory status: For research use only, not for use in humans
Availability: worldwide (3)
Content: 7.5 mL

Availability

(3)For availability in your country please contact your local representative.
 
130-017-601 $3,450.00

CliniMACS CD3 Reagent

Availability: Europe (1), USA (2), other (3)
Content: 7.5 mL

Availability

(1)In the EU, the CliniMACS System components are available as CE-marked medical devices for their respective intended use, unless otherwise stated.
(2)In the US, the CliniMACS CD34 Reagent System, including the CliniMACS Plus Instrument, CliniMACS CD34 Reagent, CliniMACS Tubing Sets TS and LS, and the CliniMACS PBS/EDTA Buffer, is FDA approved. All other products of the CliniMACS Product Line are available for use only under an approved Investigational New Drug (IND) application or Investigational Device Exemption (IDE).
(3)For availability in your country please contact your local representative.
 
273-01 price on request here

CliniMACS CD4 MicroBeads

Regulatory status: For research use only, not for use in humans
Availability: worldwide (3)
Content: 7.5 mL

Availability

(3)For availability in your country please contact your local representative.
 
130-030-401 $3,050.00

CliniMACS CD4 Reagent

Availability: Europe (1), USA (2), other (3)
Content: 7.5 mL

Availability

(1)In the EU, the CliniMACS System components are available as CE-marked medical devices for their respective intended use, unless otherwise stated.
(2)In the US, the CliniMACS CD34 Reagent System, including the CliniMACS Plus Instrument, CliniMACS CD34 Reagent, CliniMACS Tubing Sets TS and LS, and the CliniMACS PBS/EDTA Buffer, is FDA approved. All other products of the CliniMACS Product Line are available for use only under an approved Investigational New Drug (IND) application or Investigational Device Exemption (IDE).
(3)For availability in your country please contact your local representative.
 
276-01 price on request here

CliniMACS CD8 MicroBeads

Regulatory status: For research use only, not for use in humans
Availability: worldwide (3)
Content: 7.5 mL

Availability

(3)For availability in your country please contact your local representative.
 
130-030-801 $3,050.00

CliniMACS CD8 Reagent

Availability: Europe (1), USA (2), other (3)
Content: 7.5 mL

Availability

(1)In the EU, the CliniMACS System components are available as CE-marked medical devices for their respective intended use, unless otherwise stated.
(2)In the US, the CliniMACS CD34 Reagent System, including the CliniMACS Plus Instrument, CliniMACS CD34 Reagent, CliniMACS Tubing Sets TS and LS, and the CliniMACS PBS/EDTA Buffer, is FDA approved. All other products of the CliniMACS Product Line are available for use only under an approved Investigational New Drug (IND) application or Investigational Device Exemption (IDE).
(3)For availability in your country please contact your local representative.
 
275-01 price on request here

CliniMACS CD14 MicroBeads

Regulatory status: For research use only, not for use in humans
Availability: worldwide (3)
Content: 7.5 mL

Availability

(3)For availability in your country please contact your local representative.
 
130-019-101 $2,850.00
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Showing 1-10 of 36


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