Clinical applications - Immunotherapy - Engineered T cells

Engineered T cells

T cells have been found to play a pivotal role in the immune response against cancer. In fact, the adoptive transfer of T cells expressing genetically engineered chimeric antigen receptors (CARs)¹ has shown great promise in clinical studies addressing chronic or acute lymphocytic leukemia²-³. However, the preparation of CAR T cells for clinical application is quite complex and comprises numerous handling steps.

 

References
1. Chmielewski, M. et al. (2013) Front Immunol. 4: 371
2. Kalos, M. et al. (2011) Sci. Transl. Med. 3: 95ra73.
3. Maus, M. V. et al. (2014) Blood 123: 2625–2635.

Workflow


The CliniMACS Prodigy® enables the entire workflow for the manufacture of CAR T cells, from T cell selection through to cell formulation. Read more...

Products


Learn which products are used to manufacture gene-modified T cells automatically.
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Lentigen


Lentigen Technology is a leading provider of custom lentiviral vectors.

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Miltenyi Biotec Inc.
Phone: +1 800 FOR MACS
Fax:+1 877 591 1060
macs@miltenyibiotec.com
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