Clinical applications - Immunotherapy

Immunotherapy for clinical research

  • Robust – Clinical-grade cell separation for several cell types
  • Optimized – CliniMACS® System in combination with MACS® GMP Products
  • Trusted – Over 14 years of experience in cell separation
The CliniMACS® System offers a versatile range of clinical-grade cell separation reagents, which can be used within the scope of a variety of clinical protocols, such as for hematological malignancies, immunotherapy of solid tumors, viral infections, as well as autoimmune diseases and solid organ transplantation (SOT).

The use of CliniMACS Reagents for the preparation of DLI in the transplant and non-transplant setting allows the design of tailored cellular products according to the needs of a specific treatment.

Immunotherapeutic strategies have evolved using isolated antigen-specific T cells to treat infectious complications after hematopoietic stem cell transplantation (SCT) and SOT as well as malignant diseases. During recent years natural killer (NK) cells have been highlighted and explored as a potentially powerful tool for induction of anti-tumor and anti-infectious capacity in the treatment of various malignant diseases. Furthermore, many protocols that include infusion of antigen-pulsed dendritic cells in order to establish antigen-specific T cell responses, are in the in the clinical research phase.

These strategies may be used in combination with the MACS® GMP Product Line for the GMP-compliant manufacturing of cellular products including cultivation and expansion.

Engineered T cells

Engineered T cells

T cells play a pivotal role in the immune response against cancer. In fact, the adoptive transfer of T cells expressing genetically engineered chimeric antigen receptors (CARs)¹ has shown great promise in clinical studies addressing chronic or acute lymphocytic leukemia²,³. read more

Dendritic cells

Dendritic cells

Dendritic cells (DCs) play a central role in the regulation of innate and adaptive immunity. The use of DCs in immunotherapy is a promising strategy for the treatment of various diseases. For vaccination, DCs can be generated ex vivo from isolated monocytes or be directly isolated from whole blood. read more

T cells

T cells

T cells play a critical role in the regulation of immune responses and the elimination of infected or malignant cells in the human body. The adoptive transfer of donor T cells (DLI), virus-specific T cells, tumor-specific T cells, and tumor infiltrating lymphocytes (TILs) has shown promising results. read more

Treg cells

Treg cells

Naturally occurring regulatory T cells (Treg cells) have been shown to play an important role in various immunotherapeutic settings. Today’s requirements for the clinical grade manufacturing of Treg cell products include cell isolation strategies for Treg cell depletion or enrichment, as well as GMP-compliant expansion procedures. read more

NK cells

NK cells

Natural killer (NK) cell therapies are emerging worldwide as promising anti-cancer treatment tools, taking advantage of the fast cytolytic action of NK cells. Their high potential value for cell therapeutic concepts is based on the fact that NK cells do not seem to cause graft-versus-host disease (GvHD) in the allogeneic setting while being capable of killing a wide range of cells of malignant origin. read more

Stem cells

Stem cells

Stem cells could form the basis for generating immune cells and may be an option for enhancing the rate of engraftment. read more

Mesenchymal stem cells

Mesenchymal stem cells

Mesenchymal stem cells enriched for the antigen CD271 can be directly used or expanded in culture for pre-clinical or clinical applications. read more

Find products in CliniMACS Reagents
38 products available


View "10" | "50" | "100" products/page
Showing 1-10 of 38
Product Order no. Price

CliniMACS Anti-Biotin MicroBeads

Regulatory status: For research use only, not for use in humans
Availability: worldwide (3)
Content: 7.5 mL

Availability

(3)For availability in your country please contact your local representative.
 
130-019-201 $2,750.00

CliniMACS Anti-Biotin Reagent

Availability: Europe (1), USA (2), other (3)
Content: 7.5 mL

Availability

(1)In the EU, the CliniMACS System components are available as CE-marked medical devices for their respective intended use, unless otherwise stated.
(2)In the US, the CliniMACS CD34 Reagent System, including the CliniMACS Plus Instrument, CliniMACS CD34 Reagent, CliniMACS Tubing Sets TS and LS, and the CliniMACS PBS/EDTA Buffer, is FDA approved. All other products of the CliniMACS Product Line are available for use only under an approved Investigational New Drug (IND) application or Investigational Device Exemption (IDE).
(3)For availability in your country please contact your local representative.
 
173-01 price on request here

CliniMACS CD1c (BDCA-1)-Biotin for Research Use

Regulatory status: For research use only, not for use in humans
Availability: worldwide (2)
Content: 5 mL

Availability

(2)For availability in your country please contact your local representative.
 
130-025-501 $2,750.00

CliniMACS CD3 MicroBeads

Regulatory status: For research use only, not for use in humans
Availability: worldwide (3)
Content: 7.5 mL

Availability

(3)For availability in your country please contact your local representative.
 
130-017-601 price on request here

CliniMACS CD3 Reagent

Availability: Europe (1), USA (2), other (3)
Content: 7.5 mL

Availability

(1)In the EU, the CliniMACS System components are available as CE-marked medical devices for their respective intended use, unless otherwise stated.
(2)In the US, the CliniMACS CD34 Reagent System, including the CliniMACS Plus Instrument, CliniMACS CD34 Reagent, CliniMACS Tubing Sets TS and LS, and the CliniMACS PBS/EDTA Buffer, is FDA approved. All other products of the CliniMACS Product Line are available for use only under an approved Investigational New Drug (IND) application or Investigational Device Exemption (IDE).
(3)For availability in your country please contact your local representative.
 
273-01 price on request here

CliniMACS CD4 MicroBeads

Regulatory status: For research use only, not for use in humans
Availability: worldwide (3)
Content: 7.5 mL

Availability

(3)For availability in your country please contact your local representative.
 
130-030-401 $3,050.00

CliniMACS CD4 Reagent

Availability: Europe (1), USA (2), other (3)
Content: 7.5 mL

Availability

(1)In the EU, the CliniMACS System components are available as CE-marked medical devices for their respective intended use, unless otherwise stated.
(2)In the US, the CliniMACS CD34 Reagent System, including the CliniMACS Plus Instrument, CliniMACS CD34 Reagent, CliniMACS Tubing Sets TS and LS, and the CliniMACS PBS/EDTA Buffer, is FDA approved. All other products of the CliniMACS Product Line are available for use only under an approved Investigational New Drug (IND) application or Investigational Device Exemption (IDE).
(3)For availability in your country please contact your local representative.
 
276-01 price on request here

CliniMACS CD8 MicroBeads

Regulatory status: For research use only, not for use in humans
Availability: worldwide (3)
Content: 7.5 mL

Availability

(3)For availability in your country please contact your local representative.
 
130-030-801 $3,050.00

CliniMACS CD8 Reagent

Availability: Europe (1), USA (2), other (3)
Content: 7.5 mL

Availability

(1)In the EU, the CliniMACS System components are available as CE-marked medical devices for their respective intended use, unless otherwise stated.
(2)In the US, the CliniMACS CD34 Reagent System, including the CliniMACS Plus Instrument, CliniMACS CD34 Reagent, CliniMACS Tubing Sets TS and LS, and the CliniMACS PBS/EDTA Buffer, is FDA approved. All other products of the CliniMACS Product Line are available for use only under an approved Investigational New Drug (IND) application or Investigational Device Exemption (IDE).
(3)For availability in your country please contact your local representative.
 
275-01 price on request here

CliniMACS CD14 MicroBeads

Regulatory status: For research use only, not for use in humans
Availability: worldwide (3)
Content: 7.5 mL

Availability

(3)For availability in your country please contact your local representative.
 
130-019-101 $2,850.00
View "10" | "50" | "100" products/page
Showing 1-10 of 38


You have inquired prices for more than 1000 products. Therefore, the PDF generation can take a while. You may wait until the PDF download is available, or you can request an e-mail which provides you with a download link as soon as the PDF is ready.
Please enter a valid email address
E-Mail:
 
Thank you for your request. We will send you a download link as soon as the pdf is ready.
 
The requested price list is being generated now. You may close this note and keep browsing through our shop. A new window will open once the document is ready for download.
 

Customer login

Go

Forgot password?
Register for account

0 Shopping cart

Contact

Miltenyi Biotec Inc.
Phone: +1 800 FOR MACS
Fax:+1 877 591 1060
macs@miltenyibiotec.com
Contact overview

Product finder

Antibody panel builder

Toolbox

Loading...

Change country

Please select your country to continue