Clinical applications - Graft engineering - T cell depletion - Reagents

Reagents

Please find below a list of product lines that can be used for active T cell depletion.

CliniMACS® CD3/CD19 Product Line
For simultaneous T and B cell depletion.

CliniMACS TCRα/β Product Line
For TCRα/β+ T cell depletion. Aim: Maintenance of γ/δ T cells, NK cells, and graft facilitating cells in the graft. For additional removal of B cells, this product line can also be used in combination with CliniMACS CD19 Product Line.TCRα/β depletion is currently available as RUO (research use only) in the USA

CliniMACS CD45RA Product Line
For naive T cell depletion. Aim: Maintenance of memory T cells in the graft or DLI product. Part of CD34 hematopoietic stem cells are also CD45RA+. This should be considered if memory  cell infusion is planned to be combined with the initial transplant. In exceptional cases it may happen that donors have CD45+ memory T cells. This should be tested prior to any clinical application.
Find products in CliniMACS Reagents
36 products available
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Product Order no. Price

CliniMACS Anti-Biotin MicroBeads

Regulatory status: For research use only, not for use in humans
Availability: worldwide (3)
Content: 7.5 mL

Availability

(3)For availability in your country please contact your local representative.
 
130-019-201 $2,750.00

CliniMACS Anti-Biotin Reagent

Availability: Europe (1), USA (2), other (3)
Content: 7.5 mL

Availability

(1)In the EU, the CliniMACS System components are available as CE-marked medical devices for their respective intended use, unless otherwise stated.
(2)In the US, the CliniMACS CD34 Reagent System, including the CliniMACS Plus Instrument, CliniMACS CD34 Reagent, CliniMACS Tubing Sets TS and LS, and the CliniMACS PBS/EDTA Buffer, is FDA approved. All other products of the CliniMACS Product Line are available for use only under an approved Investigational New Drug (IND) application or Investigational Device Exemption (IDE).
(3)For availability in your country please contact your local representative.
 
173-01 price on request here

CliniMACS CD1c (BDCA-1)-Biotin for Research Use

Regulatory status: For research use only, not for use in humans
Availability: worldwide (2)
Content: 5 mL

Availability

(2)For availability in your country please contact your local representative.
 
130-025-501 $2,750.00

CliniMACS CD3 MicroBeads

Regulatory status: For research use only, not for use in humans
Availability: worldwide (3)
Content: 7.5 mL

Availability

(3)For availability in your country please contact your local representative.
 
130-017-601 $3,450.00

CliniMACS CD3 Reagent

Availability: Europe (1), USA (2), other (3)
Content: 7.5 mL

Availability

(1)In the EU, the CliniMACS System components are available as CE-marked medical devices for their respective intended use, unless otherwise stated.
(2)In the US, the CliniMACS CD34 Reagent System, including the CliniMACS Plus Instrument, CliniMACS CD34 Reagent, CliniMACS Tubing Sets TS and LS, and the CliniMACS PBS/EDTA Buffer, is FDA approved. All other products of the CliniMACS Product Line are available for use only under an approved Investigational New Drug (IND) application or Investigational Device Exemption (IDE).
(3)For availability in your country please contact your local representative.
 
273-01 price on request here

CliniMACS CD4 MicroBeads

Regulatory status: For research use only, not for use in humans
Availability: worldwide (3)
Content: 7.5 mL

Availability

(3)For availability in your country please contact your local representative.
 
130-030-401 $3,050.00

CliniMACS CD4 Reagent

Availability: Europe (1), USA (2), other (3)
Content: 7.5 mL

Availability

(1)In the EU, the CliniMACS System components are available as CE-marked medical devices for their respective intended use, unless otherwise stated.
(2)In the US, the CliniMACS CD34 Reagent System, including the CliniMACS Plus Instrument, CliniMACS CD34 Reagent, CliniMACS Tubing Sets TS and LS, and the CliniMACS PBS/EDTA Buffer, is FDA approved. All other products of the CliniMACS Product Line are available for use only under an approved Investigational New Drug (IND) application or Investigational Device Exemption (IDE).
(3)For availability in your country please contact your local representative.
 
276-01 price on request here

CliniMACS CD8 MicroBeads

Regulatory status: For research use only, not for use in humans
Availability: worldwide (3)
Content: 7.5 mL

Availability

(3)For availability in your country please contact your local representative.
 
130-030-801 $3,050.00

CliniMACS CD8 Reagent

Availability: Europe (1), USA (2), other (3)
Content: 7.5 mL

Availability

(1)In the EU, the CliniMACS System components are available as CE-marked medical devices for their respective intended use, unless otherwise stated.
(2)In the US, the CliniMACS CD34 Reagent System, including the CliniMACS Plus Instrument, CliniMACS CD34 Reagent, CliniMACS Tubing Sets TS and LS, and the CliniMACS PBS/EDTA Buffer, is FDA approved. All other products of the CliniMACS Product Line are available for use only under an approved Investigational New Drug (IND) application or Investigational Device Exemption (IDE).
(3)For availability in your country please contact your local representative.
 
275-01 price on request here

CliniMACS CD14 MicroBeads

Regulatory status: For research use only, not for use in humans
Availability: worldwide (3)
Content: 7.5 mL

Availability

(3)For availability in your country please contact your local representative.
 
130-019-101 $2,850.00
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