CD133 MicroBead Kit ( #130-050-801 )

CD133 MicroBead Kit

Description

CD133 is regarded as an important marker for the identification and isolation of primitive stem and progenitor cells from both hematopoietic and nonhematopoietic tissues. CD133⁺ cells have shown a capacity for pluripotent tissue differentiation, including to neural lineages¹. CD133⁺ isolated from fetal liver², umbilical cord blood³, bone marrow⁴, mobilized blood⁵, and skin⁶are capable of in vitro differentiation to neuronal cells as well as to astrocytes^{2,3, 5}, oligodendrocytes^3,5, and glial cells³. CD133⁺ cells are also found in the human fetal brain and are therefore regarded as neural stem and progenitor cells. CD133⁺ cells isolated from human fetal brain^7-11 were able to form self-renewing neurospheres in vitro, and to differentiate into neurones^7,11 and glia^{7, 11}. Moreover, when injected into mice, human CD133⁺ cells differentiated into fully integrated neurones and glial cells^8,10 as well as astrocytes and endothelial cells⁶.

Applications

CD133⁺ cells have the capacity to differentiate into neural lineages, and are therefore regarded as neural stem and progenitor cells. CD133⁺ cells are used in basic neural stem cell research, evaluation, and expansion.

Columns

MS, LS, XS, or autoMACS® Columns.

Clone	Isotype
AC133	Mouse IgG1

Figure 1

Oligodendrocyte-like cells derived from the in vitro differentiation of magnetically selected CD133⁺ cells. Courtesy of Selim Kuçi, Tübingen, Germany.

Oligodendrocyte-like cells derived from the <i>in vitro</i> differentiation of magnetically selected CD133<sup>+</sup> cells. Courtesy of Selim Kuçi, Tübingen, Germany.