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| Overview |
BDNF stands for brain-derived neurotrophic factor, also termed abrineurin. Human BDNF is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.
Human BDNF can be used for a variety of applications, including:
- Growth and differentiation of neurons and synapses.
- Survival and differentiation factof in neuronal cell culture.
- Trk signaling.
- Stimulation of axon outgrowth in vitro.
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| Details |
Background information
BDNF is a member of the neurotrophin family. It shares high structural homology to nerve growth factor (NGF), neurotrophin 3 (NT-3) and neurotrophin 4 (NT-4), but they all operate via different high-affinity membrane receptors and differ in target specificity. BDNF has been shown to support the survival of existing neurons, the growth and differentiation of new neurons and synapses, as well as their function in the peripheral and the central nervous system. High expression levels of BDNF have been detected in the hippocampus, cerebellum, and cortex. Furthermore BDNF is expressed in the pituitary gland, spinal cord, heart, lung, and skeletal muscle. BDNF has been shown to bind with high affinity and specifically activate the cell surface TrkB tyrosine receptor kinase. The amino acid sequence of human and mouse BDNF is identical.
Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/µg (<1 EU/µg), and purities are >95%. The biological activity is tested in appropriate bioassays. |
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