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| Stemgent® Mouse Primary iPS Cells-WP5 |
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| Description |
| Stemgent™ Mouse Primary iPS Cells-WP5 were created by transducing genetically unmodified mouse embryonic fibroblasts with murine retroviruses individually encoding the four transcription factors (Oct4, Sox2, Klf4, and c-Myc) that have been shown to induce the reprogramming of adult somatic cells to a pluripotent state. The cells were derived using morphological selection criteria and without the use of GFP reporter or antibiotic resistance genes inserted into endogenous Oct4 and Nanog gene loci. Injection of Stemgent™ Mouse Primary iPS Cells-WP5 into blastocysts resulted in the generation of chimeric mice1. When cultured under standard mouse embryonic stem (ES) cell culture conditions, the morphology of Stemgent™ Mouse Primary iPS Cells-WP5 is identical to that of mouse ES cells1. The cells express the pluripotency marker SSEA-1 and demonstrate strong endogenous AP activity. The Stemgent™ Mouse Primary iPS Cells-WP5 were generated in the lab of Dr. Rudolf Jaenisch, M.D. at Whitehead Institute-MIT. Dr. Jaenisch is a recognized leader in the study of epigenetic regulation of gene expression with numerous publications focuses on ES and iPS cellular mechanisms and methodologies. |
| Disclaimer |
| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
| Specifications and technical documents |
| Specification SheetsMaterial Safety Data SheetsProtocols
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| Details |
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| Products |
| Stemgent Mouse Primary iPS Cells-WP5 |
- Stemgent Catalog # 08-0007
Components
- 2×105 cells per vial
130-095-686
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| References |
| 1. Meissner et al. (2007) Nature Biotechnology 25 (10): 1177–1181. |
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