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| Overview |
| StemoleculeTM PS48 is an allosteric small molecule that activates phosphoinositide-dependent protein kinase 1 (PDK1) by binding exclusively to the HM/PIF binding pocket rather than the ATP-binding site1,2. Current research suggests PS48 metabolically facilitates a conversion from mitochondrial oxidation to glycolysis during the reprogramming process. PS48 has been shown to enhance reprogramming efficiency by about 15-fold3. |
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| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
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| Details |
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| Products |
| Stemolecule PS48 |
- 5 mg
- Stemgent order number #04-0076
130-097-060
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| References |
| 1. Hindie et al. (2009) Nature Chem Biol 5: 758-764. |
| 2. Stroba et al. (2009) J Med Chem 52: 4683-4693. |
| 3. Zhu et al. (2010) Cell Stem Cell 7: 651-655. |
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