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| Description |
| Stemolecule™ LDN-193189 is a cell permeable, small molecule inhibitor of BMP type I receptors ALK2 and ALK3 (IC50 = 5 nM and 30 nM respectively)1. LDN-193189 was derived from structure-activity relationship studies of Dorsomorphin2 and functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation1,3. LDN-193189 only weakly inhibits ALK4, ALK5, and ALK7 (IC50 >500 nM)1. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms4,5. LDN-193189 has been used to reduce ectopic ossification in a mouse model of fibrodysplasia ossificans progressiva1. |
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| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
| Specifications and technical documents |
| Specification SheetsMaterial Safety Data Sheets
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| Details |
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| Products |
| Stemolecule LDN-193189 |
- 2 mg
- Stemgent Catalog #04-0074
130-096-226
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- 10 mg
- Stemgent Catalog # 04-0074-10
130-097-443
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| References |
| 1. Yu, P.B. et al. (2008) Nat. Med. 14: 1363-1369. |
| 2. Yu, P.B. et al. (2008) Nat. Chem. Biol. 4: 33-41. |
| 3. Cuny, G.D. et al. (2008) Bioorg. Med. Chem. Lett. 18: 4388-4392. |
| 4. Heisenberg, C.P. and Solnica-Krezel, L. (2008) Curr. Opin. Genet. Dev. 18: 311-316. |
| 5. Cain, J. E. et al. (2008) Differentiation 76: 831-842. |
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