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| Description |
| Stemolecule™ LY411575 is a selective, cell permeable, small molecule gamma secretase inhibitor which blocks Notch activation1. Notch signaling is a pathway known to regulate both differentiation and proliferation of cells in diverse adult tissues. LY411575 has been shown to promote goblet cell differentiation in mice intestine. Concurrently, LY411575 inhibits cell proliferation2. LY411575 has also been observed to promote neural differentiation of mouse embryonic stem (ES) cells3. |
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| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
| Specifications and technical documents |
| Specification SheetsMaterial Safety Data Sheets
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| Details |
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| Products |
| Stemolecule LY411575 |
- 5 mg
- Stemgent Catalog # 04-0054
130-095-972
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| References |
| 1. Curry, C. et al. (2005) Oncogene 24: 6333-6344. |
| 2. Okamoto, R. et al. (2009) Am. J. Physiol. Gastrointest. Liver Physiol. 296: G23-G35. |
| 3. Abranches, E. et al. (2009) PLoS ONE 4 (7): e6286. |
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