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| Description |
| Stemolecule™ XAV939 is a cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway. Stemolecule™ XAV939 inhibits tankyrase 1 and tankyrase 2, thus stabilizing axin and stimulating β-catenin degradation1. Current research suggests that Wnt proteins act to maintain stem cells in an undifferentiated, self-renewing state2. Wnt proteins act on a variety of stem cells that include neural, mammary and embryonic stem cells. In addition, XAV939 inhibits growth of DLD-1 cells, an APC-deficient colorectal cancer cell line1. |
| Disclaimer |
| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
| Specifications and technical documents |
| Specification SheetsMaterial Safety Data Sheets
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| Details |
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| Products |
| Stemolecule XAV939 |
- 2 mg
- Stemgent Catalog # 04-0046
130-095-591
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| References |
| 1. Huang et al. (2009) Nature 461: 614–620. |
| 2. Nusse (2008) Cell Research 18: 523–527. |
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