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| Description |
| Stemolecule™ DAPT, a cell-permeable dipeptide, inhibits γ-secretase and indirectly inhibits Notch, a γ-secretase substrate1. Since the Notch pathway is involved in the development of both the nervous system and pancreas, DAPT may be useful in modulating Notch activity in embryonic stem cell differentiation studies2. DAPT has been shown to dose-dependently decrease amyloid-β (A-β) levels via inhibition of γ-secretase in both plasma and cerebral spinal fluid3. Since amyloid-β (A-β) containing senile plaques are characteristic in Alzheimer's disease, DAPT may be useful in studies evaluating potential treatments for that disease. |
| Disclaimer |
| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
| Specifications and technical documents |
| Specification SheetsMaterial Safety Data Sheets
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| Details |
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| Products |
| Stemolecule DAPT |
- 5 mg
- Stemgent Catalog # 04-0041
130-095-590
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| References |
| 1. Dovey et al. (2001) J of Neurochem 76: 173–181. |
| 2. Crawford and Roelink (2007) Develop Dynamics 236: 886–892. |
| 3. Lanz et al. (2003) J of Phar and Exper Ther 309: 49–55. |
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