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| Description |
| Stemolecule™ IPA-3 is an allosteric inhibitor of Pak kinase activation. IPA-3 also inhibits the activation of related Pak kinase isoforms, but not more distantly related Pak kinases or other kinases. IPA-3 binds covalently to the Pak1 regulatory domain and prevents binding to the upstream activator Cdc42. Increasing data implicates Pak1 in tumorigenesis and metastasis, thus suggesting that IPA-3 could be a novel oncologic therapy. Since Pak1 is also implicated as a critical downstream effector of protein kinase C, IPA-3 may prevent differentiation in some tissue development. |
| Disclaimer |
| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
| Specifications and technical documents |
| Specification SheetsMaterial Safety Data Sheets
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| Details |
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| Products |
| Stemolecule IPA-3 |
- 5 mg
- Stemgent Catalog # 04-0037
130-095-587
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| References |
| 1. Deacon et al. (2008) Chem & Biol 15: 322–331. |
| 2. Flaiz et al. (2009) Exp Neuro 218: 137–144. |
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